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We are offering special pre-publication pricing on three upcoming titles: receive 25% off when you place your order directly with us! Discounts apply to direct purchases by individual customers only.
(Note: You do not need to be a member of our Discount Program to receive this discount; however, if you are a member or if you register on our site to become a member of our Discount Program, you will receive an additional 10% discount.)
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HIV: From Biology to Prevention and Treatment
This book provides a comprehensive review of HIV research, covering everything from the pathogenesis of HIV infection
to prevention. Contributors explore the origins and evolution of HIV, the HIV replication cycle, host-virus interactions,
host immune responses, and HIV transmission. Vaccines, cell and gene therapies, antiretroviral drugs, microbicides,
and behavioral strategies for the treatment and prevention of HIV infections are also explored.
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The Biology of Alzheimer Disease
This comprehensive volume includes contributions covering all aspects of Alzheimer disease, from our current molecular
understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Experts in the field
discuss the biochemistry and cell biology of amyloid β-protein precursor (APP), tau, presenilin, β-secretase, and
apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and
biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its
causation and pathogenesis.
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Angiogenesis: Biology and Pathology
This volume reviews the mechanisms of angiogenesis that operate in normal development and in diseases such as cancer. The
contributors review the biology of endothelial cells and discuss the key angiogenic regulators, as well as antiangiogenic
agents including microRNAs, thrombospondins, and semaphorins. Therapeutic approaches that target pathological angiogenesis,
such as the ongoing clinical trials of anti-VEGF drugs, are also covered.
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Imaging: A Laboratory Manual Kindle Edition
FREE SAMPLE!
The Kindle version of this must-have resource for molecular biologists
is now available in electronic format (via Kindle app) for your iPad, iPhone, Android,
Windows PC, Mac, Windows Phone 7, Blackberry, or Kindle device!
Imaging: A Laboratory Manual is the cornerstone of our new laboratory
manual series on imaging techniques, which have become tremendously
valuable in nearly every field of biological research. This volume is
designed as a general reference and describes the theory and practice
of a wide array of imaging methods, but becomes an even more effective
research tool in an electronic format. Visit the Kindle Store
and download the free sample material to see for yourself how this
manual comes to life with live links and beautiful full-color
illustrations.
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RNA: Life’s Indispensable Molecule
Choice subject editors recognize the most significant titles reviewed during each calendar
year by compiling their “Outstanding Academic Titles” list, which is published each January. This year
the editors collaborated in choosing from among the 2011 list their favorites for the “Top 25 Books,” and
we are pleased and proud to announce that James Darnell’s book, RNA: Life’s Indispensable Molecule, has been
included on this prestigious list.
More praise for Dr. Darnell’s book:
“RNA: Life’s Indispensable Molecule, allows undergraduates and graduate students alike to envision, grasp,
appreciate and spark fascination of the historical evolution of the importance of RNA in the context of
cellular and developmental biology. After reading this book, I have restructured my course for Harvard
undergraduates and it’s now the only required reading outside primary literature.”
—John Rinn, Harvard University
“Jim Darnell’s career in science covers the 60 or so years following the publication of the Watson-Crick structure of DNA. This
remarkable book tells a story that parallels his career, dealing at the beginning with the prehistory of research on RNA, DNA, and
proteins and then shifting into high gear with a detailed look at the history of bacterial messenger RNA and the author’s own specialty,
the RNA of eukaryotic cells....Darnell is an experienced teacher and author of textbooks. His explanations of complex experiments are superb...”
—The FASEB Journal
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Viruses, Vol. XVIII
(CSH Symposium, Vol. XVIII, 1953)
It was with the 1953 meeting that the “golden age” of Cold Spring Harbor Symposium began. It was this meeting that established the Cold
Spring Harbor Symposia as the places to be to hear the latest in the new field of molecular genetics. The Symposia volumes for these
genetics meetings served as primary sources of data in the years when Nature and Science were the only journals publishing in this
area. And of this set of meetings—from 1953 to 1966—it is the 1953 Symposium that has taken on a mythic quality.
(read more)
Hundreds of important advances in biology were announced, debated, and distilled at the Cold Spring Harbor Symposia. These
meetings, held each year on the tranquil grounds of one of the world’s leading research institutes, have been notable events in
biomedical research since 1933. Now this essential archive, dating from 1933 to 2003, is available online. Among highly influential
volumes is the 1953 meeting “Viruses” (Vol. XVIII), above is an excerpt from the exclusive new online introduction to this volume.(read more)
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A new type of online review journal
• Spanning the complete spectrum of the molecular life sciences
• Article collections that build month by month
• Written and commissioned by experts in each field
Read these essential papers in this month’s issue:
The matrisome: Richard Hynes catalogs ECM constituents.
Completion of genome sequences for many organisms allows a reasonably complete definition of the complement of extracellular matrix (ECM) proteins.
In mammals this “core matrisome” comprises ˜300 proteins. In addition there are large numbers of ECM-modifying enzymes, ECM-binding growth factors,
and other ECM-associated proteins.
Read the full text.
Steven Benner discusses strategies for studying RNA’s role in the origin of life.
No community-accepted scientific methods are available today to guide studies on what role RNA played in the origin and early evolution
of life on Earth. Further, a definition-theory for life is needed to develop hypotheses relating to the “RNA First” model for the origin of life.
Read the full text.
Synaptic vesicle exocytosis: Thomas Südhof reviews how neurotransmitters are released at the synaptic cleft.
Presynaptic nerve terminals release neurotransmitters by synaptic vesicle exocytosis. Membrane fusion mediating synaptic exocytosis and other intracellular membrane traffic is affected by a universal machinery that includes SNARE (for “soluble NSF-attachment protein receptor”) and SM (for “Sec1/Munc18-like”) proteins.
Read the full text.
Visit here for this month’s complete table of contents and to learn more.
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