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February 2012 In This Issue
Cold Spring Harbor Perspectives in Medicine
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Covering a broad range of topics from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies, each issue offers must-read reviews on different aspects of a variety of diseases and the tissues they affect. Read these essential papers in this month’s issue: Miquel Vila discusses mitochondrial dysfunction and neurodegeneration. Leaky vessels: Harold Dvorak on tumor vascular hyperpermeability. Dennis Selkoe outlines research efforts on Alzheimer disease. Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives Visit here for this month’s complete table of contents and to learn more. |
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Research and Save on Books — Did you know that buying directly from CSHL Press enables you to save money on any title we publish? As a member of our Discount Program, you will enjoy prices that are frequently lower than those of any other online site – including Amazon. Regardless of where you make your purchase, all revenue from sales of CSHL Press publications supports research at Cold Spring Harbor Laboratory. However, when you buy directly from our website, you provide a greater level of assistance. As a member of our Discount Program, you will also be the first to hear about new titles arriving in our warehouse and will receive exclusive special offers. For complete details, click here. |
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“...Misteli is one of the most creative and productive recent arrivals in the nucleus field, as is his former postdoc mentor, David Spector....every chapter in the book was written by undeniable world leaders....The coverage is complete in that there is no structure or function of the nucleus that does not have a chapter....the book has all of the hallmarks of the fine publishing house that is Cold Spring Harbor Laboratory Press....The result is a book about the nucleus that will not be surpassed anytime soon.” —The FASEB Journal “The 28 chapters are organized to provide a comprehensive overview of nuclear compartments and their components (e.g. nuclear membrane, nuclear pore complex, chromosome territories, Cajal body, nucleolus), to discuss how this organization relates to function (transcription, DNA replication and repair, RNA processing) and to describe the defects in nuclear organization in human disease. The focus is primarily on the nucleus in mammalian cells, but there are also discussions on other simpler model organisms — budding yeast, Caenorhabditis elegans and Drosophila. Each chapter is relatively short and accessible, making this a great resource to dip into. Illustrations are used sparingly but are well chosen....if your interest in the nucleus is piqued, then this book is a good place to start.” —Development
“Imaging in Developmental Biology is an excellent resource from which both novices and experienced researchers can obtain current state-of-the-art embryo-imaging protocols for studying key developmental events, such as cell-fate determination, morphogen gradient formation, cell-cell interactions, cell migration and morphogenesis....comment often expressed was: “I did not know that we could do so much!” Upon first perusal, this comprehensive book seems almost overwhelming with an impressive 57 chapters and seven appendices. But it does contain just about everything known about imaging embryos. This is not surprising as the volume is based, in part, on the popular and excellent Cold Spring Harbor imaging course....The book is pleasant to read, with its clever use of illustrations, photos and online protocol videos....we highly recommend this book and hope that multidisciplinary collaborative expertise in biology, imaging, image analysis, computer science, visualization and database construction will continue to fast-forward 4D imaging techniques and, consequently, our knowledge of development.” —Development
“Darnell’s book is not only a bible but a lexicon. Every key experiment from the past seven decades that shaped current appreciation of the multiple roles of cellular RNA molecules is described with clarity in several succinct sentences....RNA: Life’s Indispensable Molecule should be required reading, as well as a handy desktop reference, for everyone charged with teaching gene expression on any level. It really does say it all.” —Joan A. Steitz in Science |
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When you order one or more of the titles below (at a 25% discount!), you will receive 10% off all other full price books included in your order! Offer valid through 2/29/2012 on direct purchases by individual customers only.
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Free sample available at the Kindle Store!
Save on The Honest Look and Experimental Heart. These two exciting novels are now available at a new, reduced price of only $4.99 each!
Be sure to review our other Kindle editions:
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We are offering special pre-publication pricing on three upcoming titles:
Discounts apply to direct purchases by individual customers only. |
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The articles below were specially selected by our journal editors and are freely available to read. |
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Experimental Methods for Examining Synaptic Plasticity in Drosophila.
NF-κB, the first quarter century: remarkable progress and outstanding questions.
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. |
We have recently added many new titles to our Sale Shelf. Don’t miss this opportunity to add quality books to your library at price reductions of 50% and more. Quantities are limited, so don’t delay! Here are just a few of those newly reduced:
(Sale Shelf discounts apply to direct purchases by individual US and Canada customers only. Please note that all sales are final.) |
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Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Separate cancer studies, but a single suspicion of bacteria In this special issue focusing on Cancer Genomics, Genome Research published two studies describing the surprising association of a single type of bacterium with colorectal cancer. The New York Times reported on these works, explaining how two research groups independently found the rare Fusobacterium in colon tumors, raising the potential of using the bacteria as a diagnostic biomarker or even a therapeutic target. Time magazine also lauded this finding in their list of the "Top 10 Medical Breakthroughs" of 2011.
Methylphenidate enhances extinction of contextual fear.
Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome. |
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• Spanning the complete spectrum of the molecular life sciences Read these essential papers in this month’s issue: Building muscle: Michael Rudnicki on the control of myogenesis. Ron Breaker reviews riboswitches. The matrisome: Richard Hynes catalogs ECM constituents. Follow Cold Spring Harbor Perspectives on Twitter: twitter.com/cshperspectives Visit here for this month’s complete table of contents and to learn more. Read the complete launch press release here. |
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From the Preface of Gene Function in Prokaryotes: The Cold Spring Harbor Monograph Archive offers the complete collection of scholarly monographs published by Cold Spring Harbor Laboratory Press from 1970 to 2009. The archive's 59 full-text volumes provide the life science community with definitive reviews of progress in areas of molecular, cell, and developmental biology, genetics, evolutionary biology, neuroscience, cancer biology, and molecular pathology. Each text is written and commissioned by foremost researchers in their particular discipline. It is available online as a complete collection for one-time purchase (with perpetual access) or on pay-per-view basis by book chapter.
Cold Spring Harbor Monograph Archive |
RNA: Life’s Indispensable Molecule Generation and Interpretation of Morphogen Gradients An Introduction to Nervous Systems |
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Drosophila Neurobiology: A Laboratory Manual is “an unparalleled resource for the fly neurobiology novice and aficionado” according to a recent review in The Quarterly Review of Biology. Konrad Zinsmaier, the reviewer, described the book as an “almost ‘foolproof’ manual” in which each chapter is “well organized, and features a concise introduction, critical references, and detailed experimental protocols.” One such article, which outlines methods and tools for studying synaptic plasticity in Drosophila, is featured in this month’s issue of Cold Spring Harbor Protocols. The Drosophila larval neuromuscular junction (NMJ) is a well-established model for studying synaptic function; both the motor neurons and the target muscle cells can be directly manipulated at the cellular and molecular levels. In the article, Haig Keshishian provides an overview of experimental genetic methods to manipulate these synaptic connections — including the use of mutated or reengineered ion channels. He also discusses environmental and rearing conditions that phenocopy the genetic approaches that affect synaptic function. The article is freely accessible from Cold Spring Harbor Protocols here. For more information about Drosophila Neurobiology: A Laboratory Manual, click here. |
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Cold Spring Harbor Laboratory is a private, nonprofit institution for research and education in the biological sciences. The Lab is internationally recognized for its excellence in research in cancer, neurobiology, plant genetics, and bioinformatics, and offers a broad range of educational programs for professional scientists and scientists-in-training, from elementary school students to Nobel laureates. Check the job listings below for opportunities to become a part of this important institution. Here are a few that are currently listed:
Check out the latest job opportunities at Cold Spring Harbor Laboratory HERE. |
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2012 CSHL Meetings & Conferences |
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Cold Spring Harbor Laboratory's DNA Learning Center (DNALC) is the world’s first science center devoted entirely to genetics education.
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For questions regarding journal subscriptions and site licensing, please contact: Kathy Cirone |
For all other inquiries, please contact: Geraldine Jaitin |
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