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Introducing three new titles from Cold Spring Harbor Laboratory Press

10/04/2011

Introducing three new titles from Cold Spring Harbor Laboratory Press:

Germ Cells

In sexually reproducing organisms, germ cells give rise to gametes and serve as the link between generations. A key event during germ cell development is the decision to leave mitosis and enter meiosis, leading to the formation of mature eggs and sperm. Germ cell development involves unique gene expression programs and the establishment of epigenetic marks that ensure success during fertilization and embryo development.

Written and edited by experts in the field, this volume reviews the biology of germ cells in metazoans. The contributors describe the undifferentiated state of germline stem cells, the triggers for meiotic entry, and the transcriptional and post transcriptional controls during spermatogenesis and oogenesis that lead to the formation of mature gametes. The expression of sex linked genes and the establishment of genomic imprinting in the germline are also covered.

<>This volume, which includes discussions of gamete recognition proteins, egg activation, and genetic reprogramming following nuclear transfer, is an indispensable reference for cell, molecular, and developmental biologists and anyone wishing to understand the implications of germ cell biology for reproductive technologies.

About the book:

Germ Cells was edited by Paolo Sassone-Corsi, University of California, Irvine; Margaret T. Fuller, Stanford University and Robert Braun, Jackson Laboratory and published by Cold Spring Harbor Laboratory Press (© 2011). It is available in hardcover (978-1-936113-51-4. It is 222 pages in length and contains 26 color and 12 b/w illustrations. For more information, click here

The Golgi

Identified more than 100 years ago by Camillo Golgi, the Golgi is a series of flattened cisternae that acts as a critical sorting and processing station for intracellular traffic. It receives cargo in vesicles exported from the endoplasmic reticulum and then dispatches this to the plasma membrane for secretion or directs it to other organelles, such as endosomes. The Golgi also plays an important role in carbohydrate metabolism: It is the major site for attachment of sugar moieties to proteins.

Written and edited by experts in the field, this volume includes contributions that review the current models for Golgi traffic and detail the functions of the cargo carrying machinery, such as the COPI and COPII vesicles, the glycosidases and glycosyltransferases that determine the oligosaccharide composition of the cargo, the various sorting signals, GTPases, and adaptor proteins involved, and the tethers and SNAREs that mediate vesicle fusion and deliver the cargo to the next compartment on the pathway. The contributors also examine recent insights into Golgi architecture and positioning, and the way the Golgi fragments and regenerates during cell division.

This volume, which includes discussions of Golgi bypass mechanisms, the evolution and diversity of the Golgi, and the involvement of Golgi in development and human inherited diseases, serves as a comprehensive reference for all cell biologists interested in this intriguing organelle.

About the book:
The Golgi was edited by Graham Warren, University of Vienna and James Rothman, Yale University and published by Cold Spring Harbor Laboratory Press (© 2011). It is available in hardcover (978-0-87969-873-7). It is 322 pages in length and contains 56 color and 12 b/w illustrations. For more information, click here

Calcium Signaling

Calcium ions play a critical role in signaling in a wide variety of cells and tissues, including muscle, immune cells, neurons, the liver, and oocytes. They can enter the cytoplasm from the extracellular environment or from intracellular stores and control the activity of numerous enzymes, other signaling molecules, transcription factors, and cytoskeletal components.

Written and edited by experts in the field, this volume explores the channels and pumps that transport calcium between different compartments and the regulation of calcium fluxes. The contributors discuss calcium buffers and sensors and how these produce distinct spatiotemporal calcium signals in different circumstances.

Including discussions of calcium signaling during development and normal physiology, as well as perturbed signaling in diseases such as diabetes, neurodegeneration, and atherosclerosis, Calcium Signaling is an indispensable reference for biochemists, cell and developmental biologists, and physiologists seeking a comprehensive treatment of calcium biology.

About the book:

Calcium Signaling was edited by Martin D. Bootman, The Babraham Institute; Michael J. Berridge, The Babraham Institute James W. Putney, National Institutes of Health and H. Llewelyn RoderickThe Babraham Institute  and published by Cold Spring Harbor Laboratory Press (© 2011). It is available in hardcover (978-0-87969-903-1). It is 499 pages in length and contains 71 color and 11 b/w illustrations. For more information, click here

Contact:
Elizabeth Powers, Book Marketing and Sales Account Manager
powerse@cshl.edu ; 516-422-4101

About Cold Spring Harbor Laboratory Press:

Cold Spring Harbor Laboratory Press is an internationally renowned publisher of books, journals, and electronic media, located on Long Island, New York. Since 1933, it has furthered the advance and spread of scientific knowledge in all areas of genetics and molecular biology, including cancer biology, plant science, bioinformatics, and neurobiology. The Press is a division of Cold Spring Harbor Laboratory, an innovator in life science research and the education of scientists, students, and the public. For more information, visit www.cshlpress.com.



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