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Ras signaling and Lung Cancer

03/15/2007

Ras signaling and Lung Cancer

In the March 15th issue of Genes & Development, Dr. Tyler Jacks (MIT) and colleagues lend new insight into the contribution that the ras oncogene makes to developmental disorders and cancer. The researchers studied a common, cancer-associated activating mutation of K-ras in the mouse to ascertain how oncogenic K-ras signaling perturbs lung development and may promote neoplasia. They found that Sprouty-2 regulates oncogenic K-ras activity in the developing lung through downregulation of MAPK activity, and posit that Sprouty-2 may function as a tumor suppressor in K-ras-driven lung tumors.


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