New book on The Cytoskeleton from Cold Spring Harbor Laboratory Press|
The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems--actin, microtubules, and intermediate filaments--along with a host of adaptors, regulators, molecular motors, and additional structural proteins.
The Cytoskeleton, published by Cold Spring Harbor Laboratory Press, presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.
IMAGE: Immunofluorescence micrograph of a rat fibroblast stained simultaneously for microtubules (green), actin filaments (blue), and vimentin-type intermediate filaments (red).
CREDIT:The specimen was prepared and imaged by Rosmarie Suetterlin and Cora-Ann Schoenenberger at the Maurice E. Muller Institute for Structural Biology (Ueli Aebi, head), Biozentrum, University of Basel, Switzerland.