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The Mammary Gland as an Experimental Model

08/15/2011

Studies of mammary gland biology are essential in the fight against breast cancer.As described in a new book from Cold SpringHarbor Laboratory Press, The Mammary Gland as an Experimental Model,this organ also represents an excellent model system for investigation of physiological and pathological processes that occur throughout the body. The branching morphogenesis that occurs during puberty and the alveogenesis during pregnancy, for example, recapitulate steps that occur in many tissues during embryogenesis and are also relevant to tumor invasion and metastasis. Similarly, analyses of breast cancer progression and the cell types that contribute to it yield findings applicable not only to breast cancer but widely to other cancers as well.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of mammary gland development, physiology, and tumor formation, emphasizing the value of the organ as a model system. The contributors examine the roles of hormones, growth factors, oncogenes, and the extracellular matrix in normal development and cancer. In addition, they discuss the nature of the mammary gland stem cell population and review the gene expression programs activated and chromatin modifications that occur as the different cell lineages present differentiate.

The book also contains chapters covering the many experimental approaches that have been used in this field, including transplantation, genetic engineering, RNA interference and genomics, three-dimentional culture models, and live cell imaging. It will thus be of interest to all researchers working in cell, developmental, and cancer biology as well as those focused specifically on mammary gland biology and breast cancer.

Contact:
Elizabeth Powers, Book Marketing and Sales Account Manager
powerse@cshl.edu ; 516-422-4101

About the book:

TheMammary Gland as an Experimental Model was edited by Mina J. Bissell, Lawrence Berkeley National Laboratory; Kornelia Polyak, Harvard Medical School; and Jeffrey M. Rosen, Baylor College of Medicine, and published by Cold Spring Harbor Laboratory Press (2011). It is available in hardcover (978-0-879699-06-2). It is 325 pages in length and contains 54 color and 5 b/w illustrations. For more information, see www.cshlpress.com/link/mamgland.htm

Cold Spring Harbor Laboratory Press is an internationally renowned publisher of books, journals, and electronic media, located on Long Island, New York. Since 1933, it has furthered the advance and spread of scientific knowledge in all areas of genetics and molecular biology, including cancer biology, plant science, bioinformatics, and neurobiology. The Press is a division of Cold Spring Harbor Laboratory, an innovator in life science research and the education of scientists, students, and the public. For more information, visit www.cshlpress.com.



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