Two independent, upcoming G&D papers lend new insight into the expression of microRNAs and their targets during vertebrate development. Dr. David Bartel and colleagues describe a novel experimental system for genome-wide quantitative analysis of miRNA target expression in miRNA-expressing cells. They found that in the developing zebrafish embryo, miRNA targets are commonly expressed at lower levels in miRNA-expressing cells, suggesting that miRNAs work in concert with other regulatory processes to dampen target gene expression in specific miRNA-expressing cells. Separately, Dr. Antonio Giraldez and colleagues detail their identification of the muscle-specific miRNA targets in the zebrafish embryo. They report that miR-1 and miR-133 are they key muscle regulatory miRNAs, and that they function by mediating actin organization in the developing muscle.
Coherent but overlapping expression of microRNAs and their targets during vertebrate development
Alena Shkumatava, Alexander Stark, Hazel Sive, and David Bartel
Zerbafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization
Yuichiro Mishima, Cei Abreu-Goodger, Alison A Staton, Carlos Stahlhut, Chong Shou, Chao Cheng, Mark Gerstein, Anton J Enright, and Antonio J Giraldez
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