Introducing a new book on the synthesis of proteins
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Protein Synthesis and Translational Control
Edited by John W.B. Hershey, University of California, Davis; Nahum Sonenberg, McGill University; Michael B. Mathews, New Jersey Medical School, University of Medicine and Dentistry of New Jersey
The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and a group of genetic disorders termed "ribosomopathies."
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of all aspects of protein synthesis and its control. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high-resolution structures of translational machinery where this takes place. They review the targets of translational control (e.g., initiation factors, mRNAs, and ribosomes) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs are also covered.
This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as cancer biologists and all those investigating human diseases associated with translation dysfunction.
2012, 352 pp., illustrations, index
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