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Download a Free Excerpt from Prion Biology: Preface Functional Prions in the Brain Index
Download a Free Excerpt from Prion Biology:
Preface Functional Prions in the Brain Index
© 2017 456 pages, illustrated (74 color and 16 B&W), index Paperback $79 55.30 ISBN 978-1-621822-84-4 You save: 30% You will receive free shipping on this item at checkout. Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only. This title also available in: Hardcover Print Book + eBook Best value! $154 $71.10 Print Book$79 $55.30 eBook$75 $60.00 Bulk discounts available for your lab or class. Click here to inquire. eBooks use Adobe Digital Editions software. Click here for more information.
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Prions are best known as the infectious proteins causing mad cow and related diseases, and a growing number of proteins with similar properties are implicated in disorders such as Alzheimers and Parkinsons. But some recently discovered prion proteins do not seem to induce pathological changes and, in fact, may function in basic biological processes such as transcription, immune regulation, and memory formation.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the expanding roles of prions in health and disease. The contributors review the structures of prion proteins and how they adopt alternative structures and aggregate into amyloid fibrils and other insoluble complexes. The alternatively folded prion forms display unique biological properties. Although some prion proteins feature in cellular dysfunction, others have normal physiological roles (e.g., CPEB in the brain and MAVS in the immune response). This volume is an essential reference for biochemists, cell and molecular biologists, and all who wish to understand how prions are formed from alternatively folded, self-propagating proteins.