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Prostate Cancer

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseDiseasesCancer Biology

Edited by Michael M. Shen, Columbia University Medical Center; Mark A. Rubin, University of Bern

Download a Free Excerpt from Prostate Cancer:

Prostate Cancer Research at the Crossroads

© 2019 • 467 pages, illustrated (72 color and 4 B&W), index
Hardcover •
ISBN  978-1-621821-64-9

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  •     Description    
  •     Contents    


Prostate cancer is the most commonly diagnosed cancer in men and causes thousands of deaths annually. Many prostate tumors are slow growing and localized to the prostate, whereas others are more aggressive and spread to other areas of the body (e.g., bones). Work to better understand prostate cancer will lead to improved treatment options and more precise care for patients with this disease.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the pathogenesis and treatment of prostate cancer. The contributors review the normal development, anatomy, and histology of the prostate; the genetic, lifestyle, and dietary factors associated with prostate cancer risk; and the alterations in the genome, epigenetic landscape, transcriptional networks, and metabolic and signaling pathways that drive oncogenesis. The role of the tumor microenvironment in prostate cancer pathogenesis is covered, as are the molecular mechanisms of metastasis. The authors also discuss how mouse models and patient-derived tissues can be used to study aspects of the disease and accelerate the development of appropriate therapies.

Other topics include methods for diagnosing and monitoring prostate cancer, such as biomarker (e.g., serum PSA) testing, histopathological grading, and anatomical and molecular imaging techniques, as well as treatment options that are currently available and under development. Strategies that may prevent prostate cancer altogether (e.g., chemoprevention) are also described. This volume is therefore a vital reference for all cancer biologists and clinician–scientists concerned with defeating this disease.


Charles L. Sawyers
Prostate Cancer Research at the Crossroads
Michael M. Shen and Mark A. Rubin
Anatomy and Histology of the Human and Murine Prostate
Michael Ittmann
Prostate Organogenesis
Jeffrey C. Francis and Amanda Swain
The Epidemiology of Prostate Cancer
Claire H. Pernar, Ericka M. Ebot, Kathryn M. Wilson, and Lorelei A. Mucci
Prostate Cancer Germline Variations and Implications for Screening and Treatment
Alexander Dias, Zsofia Kote-Jarai, Christos Mikropoulos, and Ros Eeles
Prostate Cancer Disparities by Race and Ethnicity: From Nucleotide to Neighborhood
Timothy R. Rebbeck
Histopathology of Prostate Cancer
Peter A. Humphrey
Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia: Challenges and Opportunities
Levent Trabzonlu, Ibrahim Kulac, Qizhi Zheng, Jessica L. Hicks, Michael C. Haffner, William G. Nelson, Karen S. Sfanos, Onur Ertunc, Tamara L. Lotan, Christopher M. Heaphy, Alan K. Meeker, Srinivasan Yegnasubramanian, and Angelo M. De Marzo
Prostate Stem Cells and Cancer Stem Cells
Jia J. Li and Michael M. Shen
Transcriptional Regulation in Prostate Cancer
David P. Labbé and Myles Brown
Prostate Cancer Epigenetics: From Basic Mechanisms to Clinical Implications
Srinivasan Yegnasubramanian, Angelo M. De Marzo, and William G. Nelson
The Genomics of Prostate Cancer: A Historic Perspective
Mark A. Rubin and Francesca Demichelis
Chemoprevention in Prostate Cancer: Current Perspective and Future Directions
J. Ricardo Rivero, Jr., Ian M. Thompson, Jr., Michael A. Liss, and Dharam Kaushik
Androgen Signaling in Prostate Cancer
Charles Dai, Hannelore Heemers, and Nima Sharifi
New Opportunities for Targeting the Androgen Receptor in Prostate Cancer
Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler, and Wayne D. Tilley
Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models, and Therapies
Loredana Puca, Panagiotis J. Vlachostergios, and Himisha Beltran
DNA Damage Response in Prostate Cancer
Matthew J. Schiewer and Karen E. Knudsen
Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance
Christine Levesque and Peter S. Nelson
Metastases in Prostate Cancer Federico La Manna, Sofia Karkampouna, Eugenio Zoni, Marta De Menna, Janine Hensel, George N. Thalmann, and Marianna Kruithof-de Julio
Genetically Engineered Mouse Models of Prostate Cancer in the Postgenomic Era
Juan M. Arriaga and Cory Abate-Shen
Preclinical Models of Prostate Cancer: Patient-Derived Xenografts, Organoids, and Other Explant Models
Gail P. Risbridger, Roxanne Toivanen, and Renea A. Taylor
Preclinical and Coclinical Studies in Prostate Cancer
Ming Chen and Pier Paolo Pandolfi
Metabolic Vulnerabilities of Prostate Cancer: Diagnostic and Therapeutic Opportunities
Giorgia Zadra and Massimo Loda
Molecular Biomarkers in the Clinical Management of Prostate Cancer
Aaron M. Udager and Scott A. Tomlins
Anatomic and Molecular Imaging in Prostate Cancer
Eric T. Miller, Amirali Salmasi, and Robert E. Reiter
Immunotherapy for Prostate Cancer
Nicholas J. Venturini and Charles G. Drake
Treatment of Advanced Prostate Cancer—A Review of Current Therapies and Future Promise
Semini Sumanasuriya and Johann De Bono