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Cell Survival and Cell Death, Second Edition

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Cell BiologyCancer Biology

Edited by Kim Newton, Genentech; James M. Murphy, Walter and Eliza Hall Institute of Medical Research; Edward A. Miao, Duke University

Download a Free Excerpt from Cell Survival and Cell Death, Second Edition:

The Evolutionary Origins of Programmed Cell Death Signaling

© 2020 • 310 pages, illustrated (61 color), index
Hardcover •
ISBN  978-1-621823-55-1

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  •     Description    
  •     Contents    


In multicellular organisms, cell death is required for normal development, homeostasis, and the elimination of infected or injured cells. The mechanisms by which cell death occurs are genetically encoded and carefully controlled. Perturbations that enhance or suppress cell death may lead to cancer, neurodegeneration, and inflammatory diseases.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on the cell signaling that underlies the main cell death programs (apoptosis, pyroptosis, and necroptosis) and how this knowledge is driving the development of therapeutic drugs to treat some human diseases. Contributors describe in detail the molecular mechanisms of cell death signaling and the myriad players involved, including death receptor–ligand systems, BCL-2 family proteins, caspases, inflammasomes, gasdermin, MLKL, RIPK1, A20, and XIAP. They also examine the involvement of cell death programs in various pathologies and the therapeutic potential of inhibiting key pathway components.

Chapters are additionally devoted to cell death signaling mechanisms in plants and lower organisms, as well as the evolution of those mechanisms and the influence of pathogens that seek to evade them. This volume is therefore an essential reference for cell and developmental biologists, cancer biologists, and all who wish to explore recent progress in our understanding of cell death programs.


The Evolutionary Origins of Programmed Cell Death Signaling
Kay Hofmann
BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins
Tudor Moldoveanu and Peter E. Czabotar
Cracking the Cell Death Code
Carla V. Rothlin and Sourav Ghosh
Phagocyte Responses to Cell Death in Flies
Andrew J. Davidson and Will Wood
Multitasking Kinase RIPK1 Regulates Cell Death and Inflammation
Kim Newton
The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL)
James M. Murphy
Death Receptors and Their Ligands in Inflammatory Disease and Cancer
Alessandro Annibaldi and Henning Walczak
Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis
Nathalia M. de Vasconcelos and Mohamed Lamkanfi
Mechanism and Regulation of Gasdermin-Mediated Cell Death
Shiyu Xia, Louis Robert Hollingsworth IV, and Hao Wu
A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity
Arne Martens and Geert van Loo
Regulation of Cell Death and Immunity by XIAP
Philipp J. Jost and Domagoj Vucic
Cell Death and Neurodegeneration
Benjamin J. Andreone, Martin Larhammar, and Joseph W. Lewcock
Programmed Cell Death in the Evolutionary Race against Bacterial Virulence Factors
Carolyn A. Lacey and Edward A. Miao
Cell-Cycle Cross Talk with Caspases and Their Substrates
Patrick Connolly, Irmina Garcia-Carpio, and Andreas Villunger
Cell Death in Plant Immunity
Eugenia Pitsili, Ujjal J. Phukan, and Nuria S. Coll
Dysregulation of Cell Death in Human Chronic Inflammation
Yue Li, Christoph Klein, and Daniel Kotlarz
Neutrophil Extracellular Traps in Host Defense
Sabrina Sofia Burgener and Kate Schroder