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The Mammary Gland as an Experimental Model

Subject Area(s):  Developmental BiologyCell BiologyCancer Biology

Edited by Mina J. Bissell, Lawrence Berkeley National Laboratory; Kornelia Polyak, Harvard Medical School; Jeffrey M. Rosen, Baylor College of Medicine

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© 2011 • 325 pp., illus. (54 color, 5 b/w), index
Hardcover •
ISBN  978-0-879699-06-2

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Studies of mammary gland biology are essential in the fight against breast cancer. Moreover, the mammary gland represents an excellent model system for investigation of physiological and pathological processes that occur throughout the body. The branching morphogenesis that occurs during puberty and the alveogenesis processes during pregnancy, for example, recapitulate steps that occur in many tissues during embryogenesis and are also relevant to tumor invasion and metastasis. Similarly, analyses of breast cancer progression and the cell types that contribute to it yield findings applicable not only to breast cancer but widely to other cancers as well.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of mammary gland development, physiology, and tumor formation, emphasizing the value of the organ as a model system. The contributors examine the roles of hormones, growth factors, oncogenes, and the extracellular matrix in normal development and cancer. In addition, they discuss the nature of the mammary gland stem cell population and review the gene expression programs activated and chromatin modifications that occur as the different cell lineages present differentiate.

The book also contains chapters covering the many experimental approaches that have been used in this field, including transplantation, genetic engineering, RNA interference and genomics, three dimensional culture models, and live cell imaging. It will thus be of interest to all researchers working in cell, developmental, and cancer biology, as well as those focused specifically on mammary gland biology and breast cancer.


Of Mice and Women: A Short History of Mouse Mammary Cancer Research with an Emphasis on the Paradigms Inspired by the Transplantation Method
Daniel Medina
A Compendium of the Mouse Mammary Tumor Biologist: From the Initial Observations in the House Mouse to the Development of Genetically Engineered Mice
Robert D. Cardiff and Nicholas Kenney
Choosing a Mouse Model: Experimental Biology in Context—The Utility and Limitations of Mouse Models of Breast Cancer
Alexander D. Borowsky
Murine Mammary Epithelial Stem Cells: Discovery, Function, and Current Status
Jane E. Visvader and Gilbert H. Smith
Stem Cells in the Human Breast
Ole William Petersen and Kornelia Polyak
Hormone Action in the Mammary Gland
Cathrin Brisken and Bert O’Malley
Mammary Gland Growth Factors: Roles in Normal Development and in Cancer
Nancy E. Hynes and Christine J. Watson
Cell–Matrix Interactions in Mammary Gland Development and Breast Cancer
John Muschler and Charles H. Streuli
Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression
Pepper Schedin and Patricia J. Keely
Oncogene and Tumor Suppressor Genes
Eva Y.H.P. Lee and William B. Muller
The Role of the Microenvironment in Mammary Gland Development and Cancer
Kornelia Polyak and Raghu Kalluri
Molecular Mechanisms Guiding Embryonic Mammary Gland Development
Pamela Cowin and John Wysolmerski
TGF-β Biology in Mammary Development and Breast Cancer
Harold Moses and Mary Helen Barcellos-Hoff
Mammary Gland Reprogramming: Metalloproteinases Couple Form with Function
Rama Khokha and Zena Werb
Leukocytes in Mammary Development and Cancer
Lisa M. Coussens and Jeffrey W. Pollard
Systems Biology and Genomics of Breast Cancer
Charles M. Perou and Anne-Lise Børresen-Dale
Using Functional Genetics to Understand Breast Cancer Biology
Alan Ashworth and Rene Bernards
Chromatin Remodeling in Mammary Gland Differentiation and Breast Tumorigenesis
Tim H.-M. Huang and Manel Esteller
In Vivo Imaging in Cancer
John Condeelis and Ralph Weissleder