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Germ Cells

Subject Area(s):  Developmental BiologyCell Biology

Edited by Paolo Sassone-Corsi, University of California, Irvine; Margaret T. Fuller, Stanford University; Robert Braun,  Jackson Laboratory

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© 2011 • 222 pp., illus. (26 4C and 12 B&W images), index
Hardcover • $135 94.50
ISBN  978-1-936113-51-4
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In sexually reproducing organisms, germ cells give rise to gametes and serve as the link between generations. A key event during germ cell development is the decision to leave mitosis and enter meiosis, leading to the formation of mature eggs and sperm. Germ cell development involves unique gene expression programs and the establishment of epigenetic marks that ensure success during fertilization and embryo development.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the biology of germ cells in metazoans. The contributors describe the undifferentiated state of germline stem cells, the triggers for meiotic entry, and the transcriptional and post transcriptional controls during spermatogenesis and oogenesis that lead to the formation of mature gametes. The expression of sex linked genes and the establishment of genomic imprinting in the germline are also covered.

This volume, which includes discussions of gamete recognition proteins, egg activation, and genetic reprogramming following nuclear transfer, is an indispensable reference for cell, molecular, and developmental biologists and anyone wishing to understand the implications of germ cell biology for reproductive technologies.


Germline Stem Cells
Allan Spradling, Margaret T. Fuller, Robert E. Braun, and Shosei Yoshida
Molecular Regulation of the Mitosis/Meiosis Decision in Multicellular Organisms
Judith Kimble
Function of the Sex Chromosomes in Mammalian Fertility
Edith Heard and James Turner
Unique Aspects of Transcription Regulation in Male Germ Cells
Helen White-Cooper and Irwin Davidson
Translational Control in Oocyte Development
Joel D. Richter and Paul Lasko
RNA Granules in Germ Cells
Ekaterina Voronina, Geraldine Seydoux, Paolo Sassone-Corsi, and Ippei Nagamori
Germ Cell Intercellular Bridges
Michael P. Greenbaum, Tokuko Iwamori, Gregory M. Buchold, and Martin M. Matzuk
Small Noncoding RNAs in the Germline
Jonathan P. Saxe and Haifan Lin
Developmental Control of Oocyte Maturation and Egg Activation in Metazoan Models
Jessica R. Von Stetina and Terry L. Orr-Weaver
Mammalian Genomic Imprinting
Marisa S. Bartolomei and Anne C. Ferguson-Smith
Nuclear Transfer to Eggs and Oocytes
J.B. Gurdon and Ian Wilmut
Selection in the Rapid Evolution of Gamete Recognition Proteins in Marine Invertebrates
Victor D. Vacquier and Willie J. Swanson