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Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Developmental BiologyCell Biology

Edited by Kenneth D. Poss, Duke University Medical Center; Donald T. Fox, Duke University Medical Center

Download a Free Excerpt from Regeneration:

Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging

© 2022 • 451 pages, illustrated (85 color and 1 B&W), index
Hardcover •
ISBN  978-1-621824-09-1

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  •     Description    
  •     Contents    
  •     Reviews    


The formation of new cells, tissues, and organs enables animals to recover from day-to-day wear and tear, injury, and disease. Some animals, such as sea stars, planarians, and lizards, can regenerate entire limbs and other body parts. But in mammals, including humans, some tissues (e.g., heart muscle) are more resistant to regeneration.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology explores the biological basis of regeneration in diverse animal species and how this knowledge can be applied therapeutically in humans. The contributors discuss the dramatic molecular and cellular changes that occur when a regeneration program is initiated, the progenitor cells and morphogenic signals involved, the formation of a blastema, the roles of reprogramming and polyploidy, the diversity of cell fates, the integration of new structures with existing body parts, and our current understanding of why some structures are more resistant to regeneration than others. The importance of technologies (e.g., single-cell RNA-seq) that have been instrumental in deciphering various aspects of regeneration in recent years is emphasized throughout.

Examples of regeneration in flatworms, Hydra, insects, salamanders, frogs, fish, and mammals are described. Several chapters are also devoted to regeneration in specific human organs—the skin, retina, heart, lung, pancreas, liver, skeletal muscle, and intestine—and examine possibilities for therapeutically replacing injured or diseased structures and for managing age-related declines in function. This volume is therefore essential reading for molecular, cell, and developmental biologists studying regeneration in animals, as well as for all interested in the development of regenerative therapies for clinical application.


Positional Information and Stem Cells Combine to Result in Planarian Regeneration
Peter W. Reddien
Cellular, Metabolic, and Developmental Dimensions of Whole-Body Regeneration in Hydra
Matthias Christian Vogg, Wanda Buzgariu, Nenad Slavko Suknovic, and Brigitte Galliot
Imaginal Disc Regeneration: Something Old, Something New
Melanie I. Worley and Iswar K. Hariharan
Insect Gut Regeneration
Peng Zhang and Bruce A. Edgar
Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration
Ivonne Sehring and Gilbert Weidinger
Positional Memory in Vertebrate Regeneration: A Century's Insights from the Salamander Limb
Leo Otsuki and Elly M. Tanaka
Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook
Devon Davidian and Michael Levin
Innate Mechanisms of Heart Regeneration
Hui-Min Yin, C. Geoffrey Burns, and Caroline E. Burns
Comparative Biology of Vertebrate Retinal Regeneration: Restoration of Vision through Cellular Reprogramming
Levi Todd and Thomas A. Reh
Pancreatic β-Cell Development and Regeneration
Natanya Kerper, Sudipta Ashe, and Matthias Hebrok
Hematopoietic Stem Cells and Regeneration
Mitch Biermann and Tannishtha Reya
All for One and One for All: Regenerating Skeletal Muscle
Sajedah M. Hindi and Douglas P. Millay
Genetic and Cellular Contributions to Liver Regeneration
Roger Liang, Yu-Hsuan Lin, and Hao Zhu
Building and Maintaining the Skin
Ya-Chieh Hsu and Elaine Fuchs
Mammalian Digit Tip Regeneration: Moving from Phenomenon to Molecular Mechanism
Gemma L. Johnson and Jessica A. Lehoczky
Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration
Brisa Palikuqi, Jérémie Rispal, and Ophir Klein
Lung Regeneration: Cells, Models, and Mechanisms
Arvind Konkimalla, Aleksandra Tata, and Purushothama Rao Tata
Axon Regeneration: A Subcellular Extension in Multiple Dimensions
Carla C. Winter, Zhigang He, and Anne Jacobi
The Diverse Manifestations of Regeneration and Why We Need to Study Them
Vidyanand Sasidharan and Alejandro Sánchez Alvarado
Polyploidy in Tissue Repair and Regeneration
Erin C. Bailey, Sara Kobielski, John Park, and Vicki P. Losick
Somatic Lineage Reprogramming
Hannah Shelby, Tara Shelby, and Marius Wernig
Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging
Thomas A. Rando and D. Leanne Jones


review:  “There is everything here that anyone needs to know about regeneration — a complete coverage of this remarkable subject. Read this volume and you do not need to read anything else.”
      —The Quarterly Review of Biology