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Bacterial Pathogenesis

Subject Area(s):  BacteriaImmunology and VaccinesMicrobiology

Edited by Pascale Cossart, Pasteur Institute; Stanley Maloy, San Diego State University

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© 2014 • 413 pages, illustrated (59 color, 10 B&W), index
Hardcover •
ISBN  978-1-936113-36-1

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  •     Description    
  •     Contents    


Bacterial illnesses—such as tuberculosis, pneumonia, typhoid fever, meningitis, and dysentery—are some of the most devastating worldwide. Although antibiotics and vaccines control their prevalence to some extent, the emergence of new virulence mechanisms and new forms of resistance to antibacterial agents makes research in this field critical to understanding and controlling infectious diseases.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology of these pathogens, their virulence mechanisms, and the host's response to infection. The contributors survey the various toxins and effectors that are used to hijack the cellular machinery of the host, and they explain how their production is coordinated and controlled. The host specificity of bacterial pathogens and the genetic basis of susceptibility are also considered. Other chapters are devoted to the pathogenic mechanisms of specific bacterial species (e.g., Salmonella, Chlamydia, and Helicobacter pylori).

The authors also describe novel vaccine strategies and antimicrobial approaches (e.g., phage therapy or biofilm disruption), as well as the use of probiotics to benefit human health. This volume is thus an essential reference for microbiologists, immunologists, and cell and molecular biologists, as well as clinicians and other public health professionals.


Bartonella and Brucella—Weapons and Strategies for Stealth Attack
Houchaima Ben-Tekaya, Jean-Pierre Gorvel, and Christoph Dehio
Chlamydial Intracellular Survival Strategies
Robert J. Bastidas, Cherilyn A. Elwell, Joanne N. Engel, and Raphael H. Valdivia
In Vitro and In Vivo Model Systems for Studying Enteropathogenic Escherichia coli Infections
Robyn J. Law, Lihi Gur-Arie, Ilan Rosenshine, and B. Brett Finlay
Genome Dynamics in Legionella: The Basis of Versatility and Adaptation to Intracellular Replication
Laura Gomez-Valero and Carmen Buchrieser
Mechanisms of Francisella tularensis Intracellular Pathogenesis
Jean Celli and Thomas C. Zahrt
Echoes of a Distant Past: The cag Pathogenicity Island of Helicobacter pylori
Nicola Pacchiani, Stefano Censini, Ludovico Buti, and Antonello Covacci
Helicobacter and Salmonella Persistent Infection Strategies
Denise M. Monack
Entry of Listeria monocytogenes in Mammalian Epithelial Cells: An Updated View
Javier Pizarro-Cerdá, Andreas Kühbacher, and Pascale Cossart
Pathogenesis of Meningococcemia
Mathieu Coureuil, Olivier Join-Lambert, Hervé Lécuyer, Sandrine Bourdoulous, Stefano Marullo, and Xavier Nassif
The Pneumococcus: Epidemiology, Microbiology, and Pathogenesis
Birgitta Henriques-Normark and Elaine I. Tuomanen
The Inside Story of Shigella Invasion of Intestinal Epithelial Cells
Nathalie Carayol and Guy Tran Van Nhieu
RNA-Mediated Regulation in Pathogenic Bacteria
Isabelle Caldelari, Yanjie Chao, Pascale Romby, and Jörg Vogel
Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control
Steven T. Rutherford and Bonnie L. Bassler
Mechanisms and Biological Roles of Contact-Dependent Growth Inhibition Systems
Christopher S. Hayes, Sanna Koskiniemi, Zachary C. Ruhe, Stephen J. Poole, and David A. Low
Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era
Maria Kostakioti, Maria Hadjifrangiskou, and Scott J. Hultgren
General Aspects and Recent Advances on Bacterial Protein Toxins
Emmanuel Lemichez and Joseph T. Barbieri
Epigenetics and Bacterial Infections
Hélène Bierne, Mélanie Hamon, and Pascale Cossart
Concepts and Mechanisms: Crossing Host Barriers
Kelly S. Doran, Anirban Banerjee, Olivier Disson, and Marc Lecuit
Host Specificity of Bacterial Pathogens
Andreas Bäumler and Ferric C. Fang
A Genome-Wide Perspective of Human Diversity and Its Implications in Infectious Disease
Jérémy and Lluis Quintana-Murci
Vaccines, Reverse Vaccinology, and Bacterial Pathogenesis
Isabel Delany, Rino Rappuoli, and Kate L. Seib
Probiotics: Properties, Examples, and Specific Applications
Judith Behnsen, Elisa Deriu, Martina Sassone-Corsi, and Manuela Raffatellu
Therapeutic and Prophylactic Applications of Bacteriophage Components in Modern Medicine
Sankar Adhya, Carl R. Merril, and Biswajit Biswas