Click to Enlarge

Breast Cancer: From Fundamental Biology to Therapeutic Strategies

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseDiseasesCancer Biology

Edited by Jane E. Visvader, The Walter and Eliza Hall Institute of Medical Research; Jeffrey M. Rosen, Baylor College of Medicine; Samuel Aparicio, University of British Columbia

© 2024 • 360 pages, illustrated (37 color), index
Hardcover •
ISBN  978-1-621824-66-4

Buy the print book on Amazon.

Some of our books are temporarily unavailable to order in print format directly from CSHL Press. In the meantime we invite you to order these titles on Amazon. Please contact us with any questions.

eBook$61.62 $46.22 Add To Cart

Bulk discounts available for your lab or class. Click here to inquire.

eBooks use Adobe Digital Editions software. Click here for more information.

  •     Description    
  •     Contents    


Breast cancer is diagnosed in over two million people each year and kills more than six hundred thousand. It has numerous histological subtypes, each with different molecular properties, and a variety of genetic and environmental factors increase an individual’s risk of developing the disease.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews our understanding of breast cancer epidemiology, the molecular and cellular mechanisms underlying its progression, and recent advances in tumor prevention, detection and treatment. The contributors discuss how work using animal models, patient-derived xenografts, and organoid cultures, together with new imaging approaches, is providing new insights into the molecular pathology of breast cancer. In addition, they examine genetic and genomic determinants, the role of chromatin, and research into intra- and inter-tumor heterogeneity.

The authors also discuss tumor dormancy, the importance of the immune system in breast cancer, and ways this may be harnessed in tumor immunotherapy. This volume is therefore a vital reference for all biologists seeking to understand the biological basis of cancer, as well as immunologists and oncologists dedicated to combating this deadly disease.


Breast Cancer Histopathology in The Age of Molecular Oncology
Zuzana Kos, Torsten O. Nielsen, Anne-Vibeke Laenkholm
Epidemiology and Risk Factors for Breast Cancer: 21st Century Advances, Gaps to Address Through Interdisciplinary Science
Mary Beth Terry and Graham A. Colditz
Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk-Evaluation
Siddhartha Yadav, Fergus J. Couch, and Susan M. Domchek
Human Ductal Carcinoma in Situ: Advances and Future Perspectives
Fariba Behbod, Jennifer H. Chen, and Alastair Thompson
Gene Expression Profiling to Decipher Breast Cancer Inter- and Intra-Tumor Heterogeneity
Alexander Swarbrick, Aranzazu Fernandez-Martinez, and Charles M. Perou
Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer
Shalini Bahl, Jason S. Carroll, and Mathieu Lupien
The Breast Cancer Proteome and Precision Oncology
Jonathan T. Lei, Eric J. Jaehnig, Hannah Smith, Matthew V. Holt, Xi Li, Meenakshi Anurag, Matthew J. Ellis, Gordon B. Mills, Bing Zhang, and Marilyne Labrie
Mechanisms of Organ-Specific Metastasis of Breast Cancer
Emma Nolan, Yibin Kang, and Ilaria Malanchi
Dormancy in Breast Cancer
Erica Dalla, Amulya Sreekumar, Julio Aguirre-Ghiso, and Lewis A. Chodosh
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges
Senthil K. Muthuswamy and Joan S. Brugge
Advances in Immunocompetent Mouse and Rat Models
Wen Bu and Yi Li
The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer
Michael T. Lewis and Carlos Caldas
Multi-Dimensional Imaging of Breast Cancer
Anne C. Rios, Jacco van Rheenen, and Colinda L.G.J. Scheele
Spatial Biology of Breast Cancer
H. Raza Ali and Robert B. West
Breast Cancer Immunity: It is TIME for the Next Chapter
Daniela F. Quail, Morag Park, Alana L. Welm, and H. Atakan Ekiz
Immunotherapy Approaches for Breast Cancer Patients in 2023
Leisha A. Emens and Sherene Loi
Emerging Therapies for Breast Cancer
Shom Goel and Sarat Chandarlapaty