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Parkinson's Disease, Second Edition


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Neurobiology

Edited by Stanley Fahn, Vagelos College of Physicians and Surgeons, Columbia University; Serge Przedborksi, Vagelos College of Physicians and Surgeons, Columbia University

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Preface
Historical Perspectives of Parkinson’s Disease: Early Clinical Descriptions and Neurological Therapies
Index

© 2025 • 466 pages, illustrated (64 color and 10 B&W), index
Hardcover • $79
ISBN  978-1-621825-03-6

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  •     Description    
  •     Contents    

Description

Parkinson’s disease presents one of the most intricate challenges in neuroscience—a complex disorder with diverse motor and nonmotor symptoms, multifactorial causes, and enigmatic progression patterns. This volume, a thoroughly revised second edition, offers a comprehensive yet accessible synthesis of the clinical and biological foundations of Parkinson’s disease, written explicitly to bridge the gap between clinicians and basic scientists.

Parkinson’s Disease, Second Edition brings together leading experts to provide an integrated view of the disorder’s pathobiology, diagnosis, and emerging therapeutic strategies. It provides both historical context and an understanding of the clinical spectrum, as well as cutting-edge insights into genetics, biomarkers, the gut–brain axis, immune contributions, and neurodegenerative mechanisms.

Highlights include:

  • Up-to-date coverage of disease progression, cell-based therapies, and lipid dysregulation
  • Deep dives into α-synuclein, LRRK2, and the genetic architecture of familial and sporadic PD
  • Examination of neural circuit dysfunction and imaging correlates of symptomatology
  • New frontiers in modeling, from rodent to primate and toxin to genetic paradigms
  • Explorations of mitochondria, autophagy, and neuroimmune interactions as pathogenic drivers

Intended for neurologists, neuroscientists, molecular biologists, and translational researchers, this book is a guide to entering and contributing to the field of Parkinson’s disease research. For readers in both the clinic and the laboratory, it offers foundational knowledge and an integrative perspective in this rapidly evolving field.

Contents

Preface
Historical Perspectives of Parkinson’s Disease: Early Clinical Descriptions
and Neurological Therapies
Christopher G. Goetz
Clinical Management of Parkinson’s Disease: Features, Diagnosis, and Principles
of Treatment
Bhavana Patel, Ashley Rawls, Tracy Tholanikunnel, and Michael S. Okun
Progression in Parkinson’s Disease
Krithi Irmady and Serge Przedborski
Neuropathology of Parkinson’s Disease and Parkinsonism
Dennis W. Dickson
Genetics of Parkinson’s Disease: From Causes to Treatment
Ana Westenberger, Norbert Brüggemann, and Christine Klein
α-Synuclein in Parkinson’s Disease: 12 Years Later
Kostas Vekrellis, Evangelia Emmanouilidou, Maria Xilouri, and Leonidas Stefanis
Leucine-Rich Repeat Kinase 2: Pathways to Parkinson’s Disease
Suzanne R. Pfeffer and Dario R. Alessi
Exploring Parkinson’s through the Lens of Genomics and Bioinformatics
Vilas Menon
Functional Neuroanatomy of the Normal and Pathological Basal Ganglia
José L. Lanciego and José A. Obeso
Pathophysiology of Motor Control Abnormalities in Parkinson’s Disease
Thomas Wichmann
Imaging of Disease-Related Networks in Parkinson’s Disease
Yoshikazu Nakano, Martin Niethammer, and David Eidelberg
Dopamine Cell-Based Replacement Therapies
Saeed Kayhanian and Roger A. Barker
Addendum to Dopamine Cell-Based Replacement Therapies
Saeed Kayhanian and Roger A. Barker
α-Synuclein Biomarkers for Parkinson’s Disease
Alexandra Lodge and Julian Agin-Liebes
Modeling Parkinson’s Disease in Primates
Erwan Bezard, Margaux Teil, Marie-Laure Arotcarena, Gregory Porras, Qin Li,
and Benjamin Dehay
Toxin-Induced Animal Models of Parkinson’s Disease
Kim Tieu, Said S. Salehe, and Harry J. Brown
Animal Models of Parkinson’s Disease
Valina L. Dawson and Ted M. Dawson
The Mitochondrial Connection in Parkinson’s Disease
Eric Schon, Diana Matheoud, and Serge Przedborski
Lipid Alterations and Pathogenic Roles in Synucleinopathies
Estela Area-Gómez, Saranna Fanning, and Ulf Dettmer
Autophagy and Protein Quality Control in Parkinson’s Disease
Marta Martinez-Vicente and Miquel Vila
The Gut–Brain Axis in Parkinson’s Disease
Virginia Gao, Carl V. Crawford, and Jacqueline Burré
Adaptive Immunity and Parkinson’s Disease
Wassim Elyaman
Innate Immunity and Parkinson’s Disease
Davina B. Oludipe, Xiaoqing Du, Samia Akter, Chen Zhang, R. Lee Mosley,
Howard E. Gendelman, and Susmita Sil
Index