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Telomeres and Telomerase


Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Cell Biology; Molecular Biology; Cancer Biology

Edited by Julia Promisel Cooper, University of Colorado Anschutz Medical Campus; Eros Lazzerini Denchi, National Cancer Institute; Joachim Lingner, Ecole Polytechnique Federale de Lausanne; Hilda A. Picket, Children's Medical Research Institute

Due February 20, 2026 • 350 pages (approx.), illustrated, index
Hardcover • $79
ISBN  978-1-621824-92-3 Error: Can't open order file. Ignoring [OrderFile] contextle]

  •     Description    
  •     Contents    

Description

The past two decades have transformed telomere biology and telomerase research. Since the publication of Telomeres, Second Edition in 2006, there has been an exponential increase in publications in the field that reflects both the depth and breadth of discovery. In 2009, the award of the Nobel Prize in Physiology or Medicine to Elizabeth Blackburn, Carol Greider, and Jack Szostak recognized the pioneering work that first brought telomeres and telomerase to the forefront of modern biology and underscored the central importance of telomeres to genome stability, cellular aging, and cancer.

In the years since, the pace of progress has only accelerated. Powerful new technologies, from single-molecule imaging to large-scale genomics, proteomics, and artificial intelligence, have enabled ever more detailed insight into telomere structure, regulation, and function. There have been associated advances in diagnostics, therapeutic strategies, and clinical applications.

This volume describes the striking progress made in this rapidly advancing field, covering topics that range from the molecular architecture of telomeres and telomerase to the mechanisms underlying the alternative lengthening of telomeres pathway, and the growing interface between telomere biology, human health, and therapeutic innovation. The chapters are written by many of the leading scientists in the field, whose insights collectively offer both an authoritative reference work and an inspiration for future research.

Contents

Preliminary
Preface
Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions
Patricia L. Abreu, Valentina Riva, Luca Zardoni, and Claus M. Azzalin
Telomeres and Human Disease
Sharon A. Savage
How Shelterin Orchestrates the Replication and Protection of Telomeres
Titia de Lange
Telomere Protection in Stem Cells
Marta Markiewicz-Potoczny and Eros Lazzerini Denchi
The Role of Microhomology-Mediated End-Joining (MMEJ) at Dysfunctional Telomeres
David Billing and Agnel Sfeir
Telomere Crisis Shapes Cancer Evolution
Joe Nassour and Jan Karlseder
Mechanisms of Alternative Lengthening of Telomeres
Roderick J. O’Sullivan and Roger A. Greenberg
Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers
Jixuan Gao and Hilda A. Pickett
Biogenesis and Regulation of Telomerase during Development and Cancer
Lu Chen and Luis Francisco Zirnberger Batista
Regulation of Human Telomerase: From Molecular Interactions to Population Genetics
Annika Martin and Dirk Hockemeyer
In The Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function
Elia Zanella and Ylli Doksani
Telomere Dynamics in Zebrafish Aging and Disease
Miguel Godinho Ferreira
Structural Biology of Telomerase and Associated Factors
Zala Sekne, Patryk Ludzia, Sebastian Balch, and Thi Hoang Duong Nguyen
Life and Death without Telomerase: The Saccharomyces cerevisiae Model
Veronica Martinez-Fernandez, Aurélia Barascu, and Maria Teresa Teixeira
Telomerase RNA Shapes the Evolutionary Diversity of Telomerase RNPs
Julian J.-L. Chen and Raymund J. Wellinger
Telomere Dynamics in Human Health and Disease
Duncan M. Baird
Telomerase in Cancer Therapeutics
Silvia Siteni, Anthony Grichuk, and Jerry W. Shay
Shedding Light on Telomere Replication, Insights from the Fission Yeast Schizosaccharomyces pombe
Stéphane Coulon
Telomeres in Meiosis
Julia Promisel Cooper
Epigenetics of Human Telomeres
Nicole Bettin, Mélina Vaurs, and Anabelle Decottignies
Oxidative Stress and DNA Damage at Telomeres
Patricia L. Opresko, Samantha L. Sanford, and Mariarosaria De Rosa
Maintaining Telomeres Without Telomerase in Drosophila: Novel Mechanisms and Rapid Evolution to Save a Genus
Stefano Cacchione, Giovanni Cenci, Anne-Marie Dion-Côté, Daniel A Barbash, and Grazia Daniela Raffa
TBD
Peter Baumann
Index