Cell Migration

Click to Enlarge				Cell Migration Subject Area(s): Cell Biology Edited by Michelle Starz-Gaiano, University of Maryland, Baltimore County; Peter N. Devreotes, Johns Hopkins University School of Medicine

				Due July 7, 2026 • 525 pages (approx.), illustrated, index Hardcover • $79 ISBN 978-1-621825-31-9

Description Contents Description Nearly all cells can move, often directionally. Without migration, embryos would not take shape, the nervous system would not wire, wounds would not close, and immune defenses would falter. Yet migration also underlies inflammation and cancer metastasis, a reminder that it both sustains and undermines life. This volume, with contributions from an international team of experts, shows that our knowledge of how cells migrate is rapidly advancing and the field is very exciting one to work in. Each of the four sections of the book has a specific focus: Single-cell migration, including key features of directed movement—cell polarity and memory, excitability and inhibition of signaling, cytoskeletal force generation, adhesion and traction—and the quantitative tools needed to analyze and model them. The coordination of cells in groups, how tissues remodel and respond, and the expression of these processes in development The technological advances and experimental tools that have advanced our understanding The multiple computational and mathematical models that have provided insights and how machine learning techniques are poised to accelerate discovery There are recurring themes throughout—the interplay of biophysics and molecular signaling, the influence of microenvironment mechanics and signals, the value of standardized assays and quantitative imaging, and the power of computational modeling. Cell Migration offers both a coherent map of the field and signposts for future investigation. Contents Preface CELL BIOLOGY OF SINGLE CELL MIGRATION Collaboration of Antipodes: Synergy of Branched and Linear F-Actin during Amoeboid Cell Movement and Chemotaxis Peter J.M. van Haastert and Arjan Kortholt Leading the Way: Molecular Drivers of Single-Cell Migration Dong Li, Hui Tu, and Huaqing Cai Pulling the Back to Steer Cell Migration: Mechanisms of Structural Polarity in Confining Signaling and Protrusion Bo Gong and Tobias Meyer Leukocyte Chemotaxis and the Elusive Negative Signals that Make It Work Kwabena A. Badu-Nkansah and Sean R. Collins Neutrophil Migration: Using all the Tricks of Mesenchymal and Amoeboid Cells to Navigate Many Environments Martina Lerche and Clare M. Waterman Many Cells Make Light Work: Self-Generated Gradients Organize Dictyostelium Aggregates and Neutrophils Swarms Evelyn Strickland, John F. Durel, Allyson E. Sgro, Orion D. Weiner COORDINATED CELL MIGRATION WITHIN MULTICELLULAR ORGANISMS Collective Mesoderm and Endoderm Cell Migration during Vertebrate Gastrulation Cornelis J. Weijer Chemical and Mechanical Regulation of Leukocyte Migration Jonathan H. Schrope, Tanner F. Robertson, Milka Sarris, and Anna Huttenlocher Harnessing the Power of Drosophila Primordial Germ Cell Migration Lacy J. Barton and Benjamin Lin Neighboring Cells as Living Substrates for Guiding Collective Cell Migration during Development Hoang Anh Le and Roberto Mayor Traveling in a Pack: The Border Cells’ Collective Journey Guided by Landscapes and Chemical Cues Alexander George and Michelle Starz-Gaiano Collective Cell Migration Strategies: Patterning, Motility, and Directionality of the Posterior Lateral Line Primordium in Zebrafish Alex V. Nechiporuk and Holger Knaut Running to Their Fates: Neural Crest and Placode Migratory Behavior and Cell Fate Decisions Junpeng Gao, Hugo A. Urrutia, and Marianne E. Bronner NOVEL APPROACHES TO CELL MIGRATION Illuminating Mammalian Cell Migration in Native Tissues at Subcellular and Molecular Resolution Bhagawat C. Subramanian, Marco Heydecker, Yeap Ng, Nicolas Melis, and Roberto Weigert Soft Matter Physics Meets Cell Biology: Transitions of Collective Cell Migration in 3D Environments Mirjam M. Zegers, Pablo Gottheil, Josef Käs, and Peter Friedl Engineered In Vitro Platforms for Mechanochemical Control of Cell Migration Bishwa Ranjan Si, Qinling Yuan, Sanjiban Nath, Bhawana Agarwal, Alice Amitrano, Debanik Choudhury, and Konstantinos Konstantopoulos Guiding Cells with Light and Chemicals: A Toolbox for Dynamic Studies of Cell Migration Abhijit Deb Roy, Elmer Rho, and Takanari Inoue A Mechanometabolism Toolbox for Studying Cell Migration Katherine M. Young, Santiago Lopez, Keefer Boone, Mehmet Acikel, Xavi Gallart, and Cynthia Reinhart-King Guiding Cell Migration with Electric Fields: Mechanisms and Applications of Galvanotaxis Min Zhao, Yan Zhang, Kan Zhu, and Brian Reid COMPUTATIONAL MODELING OF CELL MIGRATION From Signals to Protrusions: Modeling Excitable Systems in Cell Migration Pablo A. Iglesias and Parijat Banerjee Organized Randomness: How Hierarchical Coupling of Excitable System and Bistable Switch Shape Spontaneous Cell Migration Masahiro Ueda, Hiroaki Takagi, and Satomi Matsuoka Modeling and Simulating Single and Collective Cell Motility Jupiter Algorta, Ali Fele-Paranj, Jack M. Hughes, and Leah Edelstein-Keshet Exploring Self-Organization of Development in the Zebrafish Posterior Lateral Line Primordium with Computer Models Ajay Chitnis Modern Modeling of Single-Cell Migration: From Membrane Tension and Galvanotaxis to Machine Learning Wenzheng Shi and Alex Mogilner Modelling Collective Cell Migration in a Data-Rich Age: Challenges and Opportunities for Data-Driven Modelling Ruth E. Baker, Rebecca M. Crossley, Carles Falcó, and Simon F. Martina-Perez Index

Cell Migration

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