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Adult Neurogenesis

(Cold Spring Harbor Monograph Series 52)

Book Series:  Cold Spring Harbor Monograph Series
Subject Area(s):  Developmental BiologyCell BiologyHuman Biology and DiseaseNeurobiology

Edited by Fred H. Gage, The Salk Institute for Biological Studies, San Diego, California; Gerd Kempermann, Center for Regenerative Therapies, Dresden, Germany; Hongjun Song, Johns Hopkins School of Medicine, Baltimore, Maryland

© 2008 • 673 pp., illus, index
Hardcover •
ISBN  978-087969784-6

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The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this collection from Cold Spring Harbor Perspectives in Biology provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesis includes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.


1. Adult Neurogenesis: A Prologue
F.H. Gage, H. Song, and G. Kempermann

In vivo approaches
2. Numerology of Neurogenesis: Characterizing the Cell Cycle of Neurostem Cells
R.S. Nowakowski and N.L. Hayes
3. Detection and Phenotypic Characterization of Adult Neurogenesis
H.G. Kuhn and D.A. Peterson
4. Evolving Methods for the Labeling and Mutation of Postnatal Neuronal Precursor Cells: A Critical Review
J.J. Breunig, J. D. Macklis, and P.R. Rakic
5. The Use of Reporter Mouse Lines to Study Adult Neurogenesis
G. Enikolopov and L. Overstreet-Wadiche
6. Retrovirus-mediated Cell Labeling
C. Zhao
In vitro approaches
7. Neurospheres
I. Singec and A. Quiñones-Hinojosa
8. Monolayer Cultures of Neuronal Stem/Progenitor Cells
J. Ray

9. Neurogenesis in the Adult Hippocampus
G. Kempermann, H. Song, and F.H. Gage
10. Adult Subventricular Zone and Olfactory Bulb Neurogenesis
D.A. Lim, Y.-C. Huang, and A. Alvarez-Buylla
11. Neurogenic Niches in the Adult Mammalian Brain
D.K. Ma, G.-l. Ming, F.H. Gage, and H. Song

12. Adult Neurogenesis: Similarities and Differences in Stem Cell Fate, Proliferation, Migration, and Differentiation in Distinct Forebrain Regions
D.C. Lie and M. Götz
13. Proneuronal Genes Drive Neurogenesis on the Road from Development to Adulthood
E.T. Buchen and S.J. Pleasure
14. The Balance of Trophic Support and Cell Death in Adult Neurogenesis
H.G. Kuhn
15. Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
J. Bischofberger and A.F. Schinder

16. Genetics and Epigenetics in Adult Neurogenesis
J. Hsieh and J.W. Schneider
17. Activity Dependency and Aging in the Regulation of Adult Neurogenesis
G. Kempermann
18. Regulation of Hippocampal Neurogenesis by Systemic Factors Including Stress, Glucocorticoids, Sleep, and Inflammation
P.J. Lucassen, C.A. Oomen, A.-M. van Dam, and B. Czéh
19. Regulation of Adult Neurogenesis by Neurotransmitters
M.-H. Jang, H. Song, and G.-l Ming

20. Adult Neurogenesis in the Olfactory Bulb
P.-M. Lledo
21. Neurogenesis and Hippocampal Memory System
D.N. Abrous and J.M. Wojtowicz
22. Computational Modeling of Adult Neurogenesis
J.B. Aimone and L. Wiskott

23. Hippocampal Neurogenesis: Depression and Antidepressant Responses
A. Sahay, R. Hen, and R.S. Duman
24. Adult Neurogenesis in Neurodegenerative Diseases
P. Brundin, J. Winkler, and E. Masliah
25. Epilepsy and Adult Neurogenesis
S. Jessberger and J.M. Parent
26. Neurogenesis Following Stroke Affecting the Adult Brain
O. Lindvall and Z. Kokaia

27. Adult Neurogenesis in Teleost Fish
G.K.H. Zupanc
28. Neurogenesis in the Adult Songbird: A Model for Inducible Striatal Neuronal Addition
S.A. Goldman
29. Adult Human Neurogenesis: A Response to Cell Loss and New Circuitry Requirements
M.A. Curtis, P.S. Eriksson, and R.L.M. Faull
30. Adult Hippocampal Neurogenesis in Natural Populations of Mammals
I. Amrein, H.-P. Lipp, R. Boonstra, and J.M. Wojtowicz


review:  “The study of adult neurogenesis has grown exponentially over the past decade. New papers are being published almost daily, making any attempt to summarize the field a daunting task. Nevertheless, the editors and authors of Adult Neurogenesis have managed to assemble a comprehensive review of current research. Organized into seven sections that encompass 30 chapters covering topics ranging from the detection of adult-generated neurons to their possible role in neurological and psychiatric disease, the book provides a truly panoramic picture. The editors acknowledge that the volume presents only a ‘snapshot’ of the current field...but its comprehensive nature makes it a valuable collection of knowledge and ideas in this burgeoning area of neuroscience.”
      —Nature Neuroscience

review:  “Given the size of the literature on the subject of neurogenesis, it would be convenient to have most of the existing information compiled in an easily accessible form. Adult Neurogenesis by Gage, Kempermann, and Song is a recently published book that fills this niche by covering many aspects of this intriguing phenomenon....[T]he book is an authoritative source that provides wide coverage of the major topics of the field.”

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