© 2023 • 368 pages, illustrated (89 color and 1 B&W), index
Hardcover • $75.00 • ISBN 978-1-621824-37-4

The endoplasmic reticulum (ER) is a network of membranes that folds, modifies, and transports proteins in eukaryotic cells. It also manufactures lipids and interacts extensively with other organelles, playing essential roles in cell growth and homeostasis.

Written and edited by experts in the field, this new collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on advances in our understanding of the structure and multiple functions of the ER. The contributors examine how proteins enter the ER, the biogenesis of membrane proteins, and the role of the ER in protein sorting and quality control. In addition, they discuss how lipids are synthesized and transported to and from the ER.

The volume reviews the architecture of the ER and the ways in which it interacts with other organelles. The consequences for metabolic health and neurodegeneration are also considered. It is thus an essential reference for cell biologists, as well as physiologists and pathologists interested in understanding the role of the ER in disease.

Preface

Mechanism of Protein Translocation by the Sec61 Translocon Complex

Samuel Itskanov and Eunyong Park

The Biogenesis of Multipass Membrane Proteins

Luka Smalinskaitė and Ramanujan S. Hegde

A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum

Alina Guna, Masami Hazu, Giovani Pinton Tomaleri, and Rebecca M. Voorhees

The Endoplasmic Reticulum and the Fidelity of Nascent Protein Localization

Michael J. McKenna and Sichen Shao

Endoplasmic Reticulum—Associated Protein Degradation

Logesvaran Krshnan, Michael L. van de Weijer, and Pedro Carvalho

The Role of the Rhomboid Superfamily in ER Protein Quality Control: From Mechanisms and Functions to Diseases

Satarupa Bhaduri, Nicola A. Scott, and Sonya E. Neal

Post-Translational Regulation of HMG CoA Reductase

Youngah Jo and Russell A. DeBose-Boyd

Evolutionary Aspects of the Unfolded Protein Response

Kazutoshi Mori

AMPylation and Endoplasmic Reticulum Protein Folding Homeostasi

Luke A. Perera and David Ron

Regulation and Functions of the ER-Associated Nrf1 Transcription Facto

Gary Ruvkun and Nicolas Lehrbach

Sorting and Export of Proteins at the Endoplasmic Reticulum

Ishier Raote, Sonashree Saxena, and Vivek Malhotra

Cargo Receptor-Mediated ER Export in Lipoprotein Secretion and Lipid Homeostasis

Xiao Wang and Xiao-Wei Chen

ER-Phagy: Quality and Quantity Control of the Endoplasmic Reticulum by Autophag

Haruka Chino and Noboru Mizushima

Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes

Takuo Osawa, Kazuaki Matoba, and Nobuo N. Noda

Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration

Andrés Guillén-Samander and Pietro De Camilli

Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum

Robert V. Farese, Jr. and Tobias C. Walther

Cholesterol Transport to the Endoplasmic Reticulum

John P. Kennelly and Peter Tontonoz

Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscal

Christopher J. Obara, Andrew S. Moore, and Jennifer Lippincott-Schwartz

Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease

Ana Paula Arruda and Güneş Parlakgül

Structure and Function of the Nuclear Pore Complex

Stefan Petrovic, George W. Mobbs, Christopher J. Bley, Si Nie, Alina Patke, and André Hoelz

Index