© 2023 • 492 pages, illustrated (79 color), index
Hardcover • $75.00 • ISBN 978-1-621824-44-2

Efficient wound healing is critical for survival and fitness of all animals. Complex signaling networks within tissues respond to injury by activating repair mechanisms that promote diverse cellular behaviors, including proliferation, migration, and new lineage choices. A better understanding of normal injury responses is essential for the development of therapies for various skin-healing disorders, including chronic wounds, and for strategies aimed at the regeneration of a fully functional skin.

Written and edited by experts in the field, this book reviews our current understanding of the cellular, molecular, and biophysical mechanisms involved in skin wound healing, as well as the function and regulation of different skin cell types, including epithelial cells, fibroblasts, immune cells, neural cells, and endothelial cells. The book includes chapters examining the regulation of wound healing by growth factors, bioelectric signals, biomechanical signals, noncoding RNAs, and the microbiome. Also covered are chronic issues associated with wound healing and potential novel therapeutic approaches to address them. The volume is therefore an essential resource not only for cell and developmental biologists, but also for clinicians interested in understanding translational approaches to development of new therapies for skin wounds.

Preface

CELL AND MOLECULAR BIOLOGY OF WOUNDS

Wound Healing Insights from Flies and Fish

Anne George and Paul Martin

Wound Healing from an Actin Cytoskeletal Perspective

Parinaz Ahangar, Xanthe L. Strudwick, and Allison J. Cowin

Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing

Min Zhao, Marco Rolandi, and R. Rivkah Isseroff

Beyond the Code: Noncoding RNAs in Skin Wound Healing

Dongqing Li, Guanglin Niu, and Ning Xu Landén

Cellular Senescence in Acute and Chronic Wound Repair

Holly N. Wilkinson and Matthew J. Hardman

BIOLOGY OF WOUND EPITHELIUM

Plasticity of Epithelial Cells during Skin Wound Healing

Xiaoyan Sun, Simon Joost, and Maria Kasper

Epithelial–Mesenchymal Plasticity and Endothelial–Mesenchymal Transition in Cutaneous Wound Healing

Remy Vu, Morgan Dragan, Peng Sun, Sabine Werner, and Xing Dai

BIOLOGY OF WOUND FIBROBLASTS

Fibroblast Heterogeneity in Healthy and Wounded Skin

Clarisse Ganier, Emanuel Rognoni, Georgina Goss, Magnus Lynch, and Fiona M. Watt

Diversity of Fibroblasts and Their Roles in Wound Healing

Dongsheng Jiang, Ruiji Guo, Hans-Günther Machens, and Yuval Rinkevich

The Role of Myofibroblasts in Physiological and Pathological Tissue Repair

Ronen Schuster, Fereshteh Younesi, Maya Ezzo, and Boris Hinz

WOUND MICROENVIRONMENT

Role of Macrophages in Wound Healing

Sebastian Willenborg, Louise Injarabian, and Sabine A. Eming

Angiogenesis in Wound Repair: Too Much of a Good Thing?

Chen Han, May Barakat, and Luisa A. DiPietro

The Wound Microbiome

Ellen K. White and Elizabeth A. Grice

WOUND REGENERATION

Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration

Allen S.W. Oak and George Cotsarelis

Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration

Yingchao Xue, Sashank K. Reddy, and Luis A. Garza

Bioinspired Strategies for Wound Regeneration

Hans I-Chen Harn, Jeffrey M. Davidson, and Cheng-Ming Chuong

The Contribution of Innervation to Tissue Repair and Regeneration

Adam P.W. Johnston and Freda D. Miller

HUMAN PERSPECTIVE

Intrinsic Networks Regulating Tissue Repair: Comparative Studies of Oral and Skin Wound Healing

Andrew M. Overmiller, Andrew P. Sawaya, Emma D. Hope, and Maria I. Morasso

Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions

Irena Pastar, Nathan C. Balukoff, Jelena Marjanovic, Vivien Y. Chen, Rivka C. Stone, and Marjana Tomic-Canic

Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin

Alexa J. Cohen, Neda Nikbakht, and Jouni Uitto

WOUND THERAPY

Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic Wounds

Eric R. Bray, Robert S. Kirsner, and Evangelos V. Badiavas

Growth Factor and Cytokine Delivery Systems for Wound Healing

Julien M.D. Legrand and Mikaël M. Martino

Engineering Immunomodulatory Biomaterials to Drive Skin Wounds toward Regenerative Healing

Sergei Butenko, Hiromi Miwa, Yingzi Liu, Maksim V. Plikus, Phillip O. Scumpia, and Wendy F. Liu

Stairways to Advanced Therapies for Epidermolysis Bullosa

Laura De Rosa, Elena Enzo, Michele Palamenghi, Laura Sercia, and Michele De Luca

Index