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Aging: Geroscience as the New Public Health Frontier, Second Edition

© 2024 • 246 pages, illustrated (22 color and 2 B&W), index
Hardcover • $61.62 55.46
ISBN  978-1-621824-31-2
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Description

Aging represents a growing challenge for modern human populations, but in many ways our longer lives also represent an opportunity. People are living longer, but diseases associated with aging place an enormous burden on health systems, caregivers, and wider society. It is critical to elucidate the fundamental biology involved so that we can develop treatments for aging itself in addition to the fatal and disabling diseases and disorders associated with it. We must also understand the socioeconomic effects of life span and health span extension and adapt institutions accordingly.

Written and edited by experts in the field, this new volume from Cold Spring Harbor Perspectives in Medicine examines recent progress in our understanding of the biology of aging, strategies that may extend health span, and the societal implications. The contributors examine the underlying molecular mechanisms that lead to aging and consider the process from an evolutionary perspective. They also explore how life span may be extended, resistance to aging-associated conditions such as Alzheimer’s disease may be enhanced, and how society would benefit from increased health span.

In addition, the authors discuss funding mechanisms for aging research and the way in which the field should develop as a discipline. This volume is thus an important reference for scientists and clinicians involved in geroscience and geriatric medicine, as well as those interested in the broader policy picture.

Contents

In Memoriam: George M. Martin (1927–2022) by Steven N. Austad
Foreword by Felipe Sierra
Preface
HISTORICAL TRANSITIONS IN PUBLIC HEALTH
From Life Span to Health Span: Declaring “Victory” in the Pursuit of Human Longevity
S. Jay Olshansky
GEROSCIENCE COMES OF AGE
Past and Future Directions for Research on Cellular Senescence
Yi Zhu, Zacharias P. Anastasiadis, Jair Machado Espindola Netto, Tamara Evans, Tamar Tchkonia, and James. L. Kirkland
Roles of NAD+ in Health and Aging
Sofie Lautrup, Yujun Hou, Evandro F. Fang, and Vilhelm A. Bohr
Evolutionary Approaches in Aging Research
Melissa Emery Thompson
Aging and Inflammation
Amit Singh, Shepherd H. Schurman, Arsun Bektas, Mary Kaileh, Roshni Roy, David M. Wilson III, Ranjan Sen, and Luigi Ferrucci
Mitochondrial Targeted Interventions for Aging
Sophia Z. Liu, Ying Ann Chiao, Peter S. Rabinovitch, and David J. Marcinek
Biological Restraints on Indefinite Survival
Jan Vijg and Steven N. Austad
Resistance and Resilience to Alzheimer’s Disease
Caitlin S. Latimer, Katherine E. Prater, Nadia Postupna, and C. Dirk Keene
HEALTH AND ECONOMIC BENEFITS OF GEROSCIENCE INTERVENTIONS
International Gains to Achieving Healthy Longevity
Andrew Scott, Julian Ashwin, Martin Ellison, and David Sinclair
Discovering Biological Mechanisms of Exceptional Human Health Span and Life Span
Sofiya Milman and Nir Barzilai
INFLUENCE OF AGING SCIENCE ON WEALTH MANAGEMENT
Personalized Financial Planning Using Applied Genetics
S. Jay Olshansky, Bradley Willcox, Kirk Ashburn, Jeffrey Stukey, and Craig Willcox
Influence of Aging Science on Global Wealth Management
Michael Hodin
FUNDING CHANNELS FOR GEROSCIENCE
Funding Life-Extension Research
Mehmood Khan
Crowdfunding and Crowdsourcing of Aging Science
Keith Comito
DISTRIBUTORS
The Funding Channels of Geroscience
Stephanie Lederman
The Role of the National Institute on Aging in the Development of the Field of Geroscience
Felipe Sierra and Ronald A. Kohanski
Index