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The Skeletal System

(Cold Spring Harbor Monograph Series 53)

Book Series:  Cold Spring Harbor Monograph Series
Subject Area(s):  Developmental BiologyOrigin and Evolution of Life

Edited by Olivier Pourquié, Stowers Institute for Medical Research, Kansas City, Missouri

View sample pages from the book here.

© 2009 • 365 pp., illus., index
Hardcover •
ISBN  978-087969825-6

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  •     Description    
  •     Contents    
  •     Reviews    


The thirteen chapters presented in this book summarize our current understanding of the development, biology, and evolution of the vertebrate skeleton. Written by experts in the field, chapters cover everything from the differentiation of chondrocytes, limb and craniofacial patterning, and the origins and evolution of bone to the genetics of human skeletal disease. It is a useful reference for scientists and clinicians wishing to learn how the skeleton is built and works.


1. Evolutionary Origin of Bone and Cartilage in Vertebrates
K.G. Ota and S. Kuratani
2. Developmental Patterning of the Limb Skeleton
K.L. Cooper and C.J. Tabin
3. Patterning and Differentiation of the Vertebrate Spine
J. Chal and O. Pourquié
4. Craniofacial Patterning
N.M. Le Douarin and S.E. Creuzet
5. Transcriptional Control of Chondrocyte Differentiation
B. de Crombrugghe and H. Akiyama
6. Growth Factors and Chondrogenesis
H.M. Kronenberg, A.P. McMahon, and C.J. Tabin
7. Transcriptional Control of Osteoblast Differentiation
G. Karsenty
8. Role of Growth Factors in Bone Development and Differentiation
S. Fujimori, D. Kostanova-Poliakova, and C. Hartmann
9. Cytokine and Growth Factor Regulation of Osteoclastogenesis
H. Takayanagi
10. Bone Mineralization
L.F. Bonewald, S.L. Dallas, and J.P. Gorski
11. Bone Remodeling: Cellular and Molecular Events
T.J. Martin and N.A. Sims
12. Genetics of Human Skeletal Disease
B.R. Olsen
13. Extracellular Matrix in the Skeleton
F. Ramirez


review:  “Skeletal biology encompasses many different approaches and contexts that have one or more aspects of vertebrate skeletons as their basis. This volume emphasizes establishment of the skeleton and regulation of skeletal development in mammals (mostly mouse) and birds (mostly chick). Within that context, the approach is integrative rather than comparative, molecular rather than morphological, and genetic rather than epigenetic...The chapters fulfill the editor's intention to provide a book that meets the expectations of specialists and surveys the field for newcomers who want an entree into avian or mammalian model systems.”
      —The Quarterly Review of Biology

review:  “[This] book provides a wealth of useful and up-to-date information written by leading investigators who are at the forefront of the field. It is particularly thorough in its coverage of skeletal patterning and skeletal cell differentiation...[It] will be a useful addition to the bookshelves of all those interested in skeletal biology.”