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Title 21st Century Genetics: Genes at Work
Unique URL http://www.cshlpress.com/link/symp-80.htm
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ISBN | 978-1-621821-47-2 |
Price | $318 |
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The 80th Cold Spring Harbor Symposium was held to mark the 150th anniversary of Gregor Mendel’s landmark 1865 presentation of his paper “Experiments on Plant Hybridization”, which laid the groundwork for modern genetics. The Symposium Proceedings addresses 21st Century Genetics: Genes at Work, and provides a current synthesis of genetic mechanisms and genome/chromosome biology. This volume spans a broad range of topics that reflect our current understanding of genetic mechanisms in humans and other organisms. Themes include chromosome biology and nuclear structure, topologically associating domains, gene-enhancer interactions, chromatin and epigenetics, gene regulation and control, developmental regulation, RNA controlling elements, maintenance of genome stability, nuclear receptors, circadian clocks and aging, and genome editing. The Conversations included in this volume are based on interviews conducted during the Symposium and offer a broader anecdotal perspective on this fascinating subject by many of the world’s leading investigators.
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Editor
Terri Grodzicker | Cold Spring Harbor Laboratory |
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Publication Date | 2016/2016 |
Bibliographic Information 361 pages, illustrated (107 color, 98 B&W), index |
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21st Century Genetics: Genes at Work
CRISPR-Cas: A Laboratory Manual
CRISPR-Cas: A Laboratory Manual
Decoding the Language of Genetics
Clocks and Rhythms
RNA: A Laboratory Manual
RNA: A Laboratory Manual
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Title 21st Century Genetics: Genes at Work
Unique URL http://www.cshlpress.com/link/symp-80p.htm
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ISBN | 978-1-621821-48-9 |
Price | $129 |
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The 80th Cold Spring Harbor Symposium was held to mark the 150th anniversary of Gregor Mendel’s landmark 1865 presentation of his paper “Experiments on Plant Hybridization”, which laid the groundwork for modern genetics. The Symposium Proceedings addresses 21st Century Genetics: Genes at Work, and provides a current synthesis of genetic mechanisms and genome/chromosome biology. This volume spans a broad range of topics that reflect our current understanding of genetic mechanisms in humans and other organisms. Themes include chromosome biology and nuclear structure, topologically associating domains, gene-enhancer interactions, chromatin and epigenetics, gene regulation and control, developmental regulation, RNA controlling elements, maintenance of genome stability, nuclear receptors, circadian clocks and aging, and genome editing. The Conversations included in this volume are based on interviews conducted during the Symposium and offer a broader anecdotal perspective on this fascinating subject by many of the world’s leading investigators.
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Editor
Bruce Stillman | Cold Spring Harbor Laboratory |
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Publication Date | 2016/2016 |
Bibliographic Information 361 pages, illustrated (107 color, 98 B&W), index |
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21st Century Genetics: Genes at Work
CRISPR-Cas: A Laboratory Manual
CRISPR-Cas: A Laboratory Manual
Decoding the Language of Genetics
Clocks and Rhythms
RNA: A Laboratory Manual
RNA: A Laboratory Manual
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Title A Cure Within: Scientists Unleashing the Immune System to Kill Cancer
Unique URL not available
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ISBN | 978-1-621822-17-2 |
Price | $24 |
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The way we treat cancer is about to change forever. This revolution—and it is precisely that—was sparked not by the invention of a new drug, but by the evolution of an entirely new way of thinking about and managing cancer. Going forward, doctors will not use pharmaceuticals to attack tumors—not directly. Rather, the oncologist will treat the patient's immune system with a drug, and then the patient will treat the tumor.
Based entirely on interviews with the investigators, this book is the story of the immuno-oncology pioneers. It's a story of failure, resurrection, and success. It's a story about science, it's a story about discovery, and intuition, and cunning. It's a peek into the lives and thoughts of some of the most gifted medical scientists on the planet.
This is not a textbook. This is a life book. This technology will save/is saving lives, and the book celebrates the living, breathing, thinking, charming, arrogant, funny, obstinate, amazing human beings who are making immuno-oncology happen.
“The stories and lives shared in this book show readers the decades of devotion and passion it takes to imagine a better world and then make it happen. If this book motivates even one more similarly talented and visionary investigator to deliver on their promise it would be a wonderful success.”
—Clifford A. Hudis, MD, FACP, FASCO
Chief Executive Officer, American Society of Clinical Oncology
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Author
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Publication Date | 2018/2018 |
Bibliographic Information 298 pages, illustrated (56 B&W), glossary, index |
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Immunity and Tolerance
Immunity and Tolerance
Orphan: The Quest to Save Children with Rare Genetic Disorders
Is It in Your Genes? The Influence of Genes on Common Disorders and Diseases that Affect You and Your Family
Abraham Lincoln's DNA and Other Adventures in Genetics
The Medical Revolution of Messenger RNA
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Title Abraham Lincoln's DNA and Other Adventures in Genetics
Unique URL http://www.cshlpress.com/link/alincpap.htm
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ISBN | 978-087969649-8 |
Price | $18 |
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Twenty-four true, wide-ranging tales of crime, history, human behavior, illness, and ethics, told from the personal perspective of the author, an eminent physician-lawyer who uses the stories to illustrate the principles of human genetics and to discuss the broader issues.
About the author: Philip R. Reilly earned his undergraduate degree at Cornell University, studied human genetics at the University of Texas Graduate School of Biomedical Sciences, and graduated from Yale Medical School in 1981. He did his medical residency at Boston City Hospital. He earned board certification in internal medicine and clinical genetics. He has served on the Board of Directors of the American Society of Human Genetics, and he is a Founding Fellow of the American College of Medical Genetics. He twice served as President of the American Society of Law, Medicine, and Ethics. During the 1990s, Reilly was the Executive Director of the Eunice Kennedy Shriver Center for Mental Retardation in Waltham, Massachusetts, a nonprofit that worked on understanding childhood and adult neurological disorders. Dr. Reilly has held faculty positions at Harvard Medical School and Brandeis University. Since 2009 he has worked as a venture partner at Third Rock Ventures in Boston where he focuses on helping to start companies to develop innovative therapies for orphan genetic diseases. Over the years he has published six books and many articles about the impact of advances in genetics. Reilly frequently works with patient groups who are concerned with rare genetic disorders.
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Author
Philip R. Reilly | Interleukin Genetics and Tufts University School of Medicine |
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Publication Date | 2000/2000 |
Bibliographic Information 339 pp., illus., indexes, references |
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Abraham Lincoln's DNA and Other Adventures in Genetics
The Strongest Boy in the World: How Genetic Information is Reshaping Our Lives
Is It in Your Genes? The Influence of Genes on Common Disorders and Diseases that Affect You and Your Family
A Cure Within: Scientists Unleashing the Immune System to Kill Cancer
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Title Addiction, Second Edition
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ISBN | 978-1-621823-50-6 |
Price | $135 |
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Addiction to psychoactive drugs found in cigarettes, alcoholic drinks, and opioid analgesics is a severe problem for society. Events associated with addiction—drug abuse, dependence, withdrawal, and relapse—involve complex neurobiological changes in the brain. To develop effective long-term treatment strategies for substance use disorders, a more complete understanding of these brain changes is needed.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive update on our understanding of the biological basis of and treatment strategies for addiction to psychoactive drugs, with an emphasis on opioids. Contributors examine the molecular targets of alcohol, cannabinoids, nicotine, stimulants, and opioids, the resulting changes to the neurocircuitry, and various genetic, environmental, developmental, and behavioral factors that influence the progression from abuse to addiction and susceptibility to relapse. Advances in animal models of addictive behavior and single-cell strategies to dissect neural circuits are also described.
In addition, the authors review compounds currently used or under development to treat substance use disorders, their pharmacological mechanisms, and challenges related to preclinical testing in animal models. This volume is an indispensable reference for all neuroscientists and those who are interested in understanding and reducing the public health burden of drug addiction.
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Editor
R. Christopher Pierce | Rutgers University Robert Wood Johnson Medical School |
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Publication Date | 2020/2020 |
Bibliographic Information 404 pages, illustrated (16 color and 9 B&W), index |
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Title Adult Neurogenesis
Unique URL http://www.cshlpress.com/link/adultneuro.htm
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ISBN | 978-087969784-6 |
Price | $135 |
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The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this collection from Cold Spring Harbor Perspectives in Biology provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesis includes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders. |
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Fred H. Gage | The Salk Institute for Biological Studies, San Diego, California |
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Publication Date | 2008/2008 |
Bibliographic Information 673 pp., illus, index |
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Title African Turquoise Killifish (Nothobranchius furzeri): A Laboratory Manual
Unique URL not available
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ISBN | 978-1-621824-60-2 |
Price | $95 |
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The African turquoise killifish Nothobranchius furzeri is a short-lived fish species that has been established as a novel vertebrate model to study aging and represents a promising system to examine various other processes. The killifish is relatively easy and inexpensive to maintain. In addition, it has a short life cycle and abundant progeny, facilitating its use. Investigation using this model organism is growing and has provided new insights into aging, age-related diseases, ecology, evolution, and embryonic diapause—a state of “suspended animation.”
This laboratory manual provides a comprehensive collection of protocols covering experimental techniques currently used to study the African turquoise killifish. Husbandry protocols describe how to set up and maintain a killifish colony and how to generate and preserve genetically engineered killifish lines. This collection also includes both general and specific methods to characterize different organs during aging, with a particular focus on the brain. Several genomics methods and analyses for unbiased characterization are also described. Finally, this manual encompasses protocols in other interesting areas of research, including injury repair, development, and embryonic diapause.
This collection should enable studies in the African turquoise killifish and other species of killifish such as the South American killifish, and includes protocols that will be useful both to groups considering the use of these systems for the first time and to those with experience in the field. We also hope that this protocol book will foster a large killifish community and will promote new studies in many different research areas.
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Publication Date | 2024/2024 |
Bibliographic Information 286 pages, illustrated (48 color and 1 B&W), index |
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Title Ageless Quest: One Scientist's Search for the Genes That Prolong Youth
Unique URL http://www.cshlpress.com/link/ageless.htm
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ISBN | 978-087969652-8 |
Price | $19.95 |
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Ageless Quest is a personal, sometimes controversial, account of the pursuit of a genetic ‘cure’ for aging by an expert in the field. The author is the Novartis Professor of Biology at the Massachusetts Institute of Technology.
Aging has always been regarded as a highly complex process with many degenerative changes leading to the cessation of life. But recent research has identified a relatively simple mechanism that governs the pace of aging.
Lenny Guarente's Ageless Quest is a scientific detective story for the baby boom generation. It offers an insider's view of an area of potentially astonishing high reward—and equally high risk.
To read Lenny Guarente's and Robert Butler's interview with Sara Davidson (The NY Times) about how the body ages and the research on trying to extend our healthy life span, click here. (You must register for free access to NYTimes.com) |
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Lenny Guarente | Massachusetts Institute of Technology |
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Publication Date | 2003/2003 |
Bibliographic Information 154 pp., illus., index |
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Title Aging: Geroscience as the New Public Health Frontier, Second Edition
Unique URL not available
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ISBN | 978-1-621824-31-2 |
Price | $79 |
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Aging represents a growing challenge for modern human populations, but in many ways our longer lives also represent an opportunity. People are living longer, but diseases associated with aging place an enormous burden on health systems, caregivers, and wider society. It is critical to elucidate the fundamental biology involved so that we can develop treatments for aging itself in addition to the fatal and disabling diseases and disorders associated with it. We must also understand the socioeconomic effects of life span and health span extension and adapt institutions accordingly.
Written and edited by experts in the field, this new volume from Cold Spring Harbor Perspectives in Medicine examines recent progress in our understanding of the biology of aging, strategies that may extend health span, and the societal implications. The contributors examine the underlying molecular mechanisms that lead to aging and consider the process from an evolutionary perspective. They also explore how life span may be extended, resistance to aging-associated conditions such as Alzheimer’s disease may be enhanced, and how society would benefit from increased health span.
In addition, the authors discuss funding mechanisms for aging research and the way in which the field should develop as a discipline. This volume is thus an important reference for scientists and clinicians involved in geroscience and geriatric medicine, as well as those interested in the broader policy picture.
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Editor
James L. Kirkland | Mayo Clinic |
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Publication Date | 2024/2024 |
Bibliographic Information 246 pages, illustrated (22 color and 2 B&W), index |
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Title Aging: The Longevity Dividend
Unique URL http://www.cshlpress.com/link/agingdiv.htm
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ISBN | 978-1-621821-63-2 |
Price | $79 |
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Aging is one of the greatest challenges currently facing society. People are living longer than ever, but many of the later years are fraught with frailty and disease, placing an enormous burden on health-care systems. Understanding the biological changes that occur during aging and developing strategies to address them are therefore urgently needed.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biological basis of aging, strategies that may extend health span, and the societal implications of delayed aging. Contributors discuss genetic variants that accelerate or protect against aging, biochemical pathways that modulate longevity (e.g., mTOR), biological consequences of aging (e.g., decline in stem cell function), and various animal models used to study aging processes. They emphasize that age-delaying interventions will yield greater health and vitality than disease-specific treatments. Drugs that may promote health span or longevity (e.g., metformin) and efforts to prevent and treat frailty (e.g., through exercise) are explored.
The authors consider the socioeconomic benefits and costs of delayed aging and also outline directions for future research and translational efforts. This volume will serve as a vital reference for all involved in the fields of geroscience and geriatric medicine, as well as anyone wishing to understand physiological processes that generate health and disease, regardless of chronological age.
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Editor
S. Jay Olshansky | University of Illinois at Chicago, School of Public Health |
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Publication Date | 2016/2016 |
Bibliographic Information 256 pages, illustrated (26 color, 5 B&W), index |
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Aging: The Longevity Dividend
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Title Ahead of the Curve: Women Scientists at the MRC Laboratory of Molecular Biology
Unique URL not available
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ISBN | 978-1-621824-52-7 |
Price | $24.95 |
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The MRC Laboratory of Molecular Biology (LMB) in Cambridge, UK is a world-leading scientific institution. This book, by LMB alumna Kathy Weston, is a collective portrait of women scientists who, as staff members, visitors, and trainees, helped build the LMB’s reputation as a powerhouse of science, often going on to stellar careers at other outstanding institutions around the world. Combining narrative history with interview transcripts and personal reminiscence, Weston’s book describes the career accomplishments of these successful scientists in the context of their lives as a whole, and how they manage goals and priorities, particularly around personal and family lives. The book provides future sisters in science with role models and inspiration but is recommended reading for everyone intent on combining success in research with a satisfying life outside science.
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Publication Date | 2021/2021 |
Bibliographic Information 304 pages, illustrated (56 color and 10 B&W), index |
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Title An A to Z of DNA Science: What Scientists Mean When They Talk about Genes and Genomes
Unique URL http://www.cshlpress.com/link/a2zgenes.htm
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ISBN | 978-087969600-9 |
Price | $16 |
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Medical science constantly demands our attention, as patients or relatives, concerned citizens, voters, investors, or simply curious individuals. But for those without training, the language of science is often hard to follow. The A to Z of DNA Science book series defines and illustrates specialized terms in ways that non-specialists can appreciate and enjoy. This volume focuses on the language of genes, genomes, DNA, biotechnology, and heredity, defining, explaining, and illustrating over 200 terms used in books, broadcasting, websites, and newspaper and magazine articles. |
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Jeffre L. Witherly | National Human Genome Research Institute, Bethesda, Maryland |
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Publication Date | September 2001/2001 |
Bibliographic Information 126 pp., illus., index |
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An A to Z of DNA Science: What Scientists Mean When They Talk about Genes and Genomes
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Title An Introduction to Animal Behavior: An Integrative Approach
Unique URL http://www.cshlpress.com/link/introanibehp.htm
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ISBN | 978-0-879698-58-4 |
Price | $46.00 |
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The study of animal behavior is one of the most integrative endeavors in biology—it encompasses how the behavior is acquired, how it works, why it has come to work as it does, and how it influences the behaving animal and the animals around it. In Animal Behavior: An Integrative Approach, Michael J. Ryan and Walter Wilczynski address the interrelationship of these aspects of animal behavior, which Nikolaas Tinbergen codified in his “four questions” as causation, ontogeny, survival value, and evolution. In light of these questions, the authors first review some of the basic concepts of ultimate and proximate aspects of behavior. They make the argument that integrating different levels of analysis is critical for deriving a correct interpretation of behavior. In subsequent chapters, they review topics such as foraging, orientation and migration, sex differences, mate choice, social bonding, cooperation, conflict, and aggression. The authors integrate information from molecular genomics through neuroscience, endocrinology, development, and learning to evolutionary genetics, selection, constraints, and phylogenetics to provide a concise but comprehensive look at current topics in animal behavior. This book provides a well-thought-out and integrated introduction to the complexity of animal behavior that should appeal to advanced undergraduates, graduate students, and professional scientists in other fields in need of a succinct review of the field. |
Author
Michael J. Ryan | The University of Texas at Austin |
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Publication Date | 2011/2011 |
Bibliographic Information 258 pp., illus. (88 color, 3 b/w), index |
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An Introduction to Animal Behavior: An Integrative Approach
Evolution
An Introduction to Nervous Systems
An Introduction to Nervous Systems
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Title An Introduction to Animal Behavior: An Integrative Approach
Unique URL http://www.cshlpress.com/link/introanibeh.htm
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ISBN | 978-1-936113-18-7 |
Price | $81.00 |
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The study of animal behavior is one of the most integrative endeavors in biology—it encompasses how the behavior is acquired, how it works, why it has come to work as it does, and how it influences the behaving animal and the animals around it. In Animal Behavior: An Integrative Approach, Michael J. Ryan and Walter Wilczynski address the interrelationship of these aspects of animal behavior, which Nikolaas Tinbergen codified in his “four questions” as causation, ontogeny, survival value, and evolution. In light of these questions, the authors first review some of the basic concepts of ultimate and proximate aspects of behavior. They make the argument that integrating different levels of analysis is critical for deriving a correct interpretation of behavior. In subsequent chapters, they review topics such as foraging, orientation and migration, sex differences, mate choice, social bonding, cooperation, conflict, and aggression. The authors integrate information from molecular genomics through neuroscience, endocrinology, development, and learning to evolutionary genetics, selection, constraints, and phylogenetics to provide a concise but comprehensive look at current topics in animal behavior. This book provides a well-thought-out and integrated introduction to the complexity of animal behavior that should appeal to advanced undergraduates, graduate students, and professional scientists in other fields in need of a succinct review of the field. |
Author
Michael J. Ryan | The University of Texas at Austin |
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Publication Date | 2011/2011 |
Bibliographic Information 258 pp., illus. (88 color, 3 b/w), index |
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An Introduction to Animal Behavior: An Integrative Approach
Evolution
An Introduction to Nervous Systems
An Introduction to Nervous Systems
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Title Angiogenesis: Biology and Pathology, Second Edition
Unique URL not available
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ISBN | 978-1-621824-34-3 |
Price | $79 |
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The growth of new blood vessels plays an important role in normal development and cancer progression. This new edition updates our understanding of the processes involved and how they may be targeted therapeutically.
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Editor
Diane R. Bielenberg | Harvard Medical School |
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Publication Date | July 2024/2024 |
Bibliographic Information 450 pages (approx.), illustrated, index |
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Title The Annotated and Illustrated Double Helix
Unique URL http://www.cshlpress.com/link/autoillus.htm
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ISBN | 978-1-476715-49-0 |
Price | $Not for Sale |
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The structure of DNA deduced by James Watson and Francis Crick in 1953 was one of the most significant scientific discoveries of the 20th century. Fifteen years later, Watson wrote The Double Helix, his classic account of the discovery. It was something new, a description of science in action written not as a formal autobiography or a measured history, but in the voice of a brash, ambitious young man who knew the big question in biology and wanted the answer. In this edition, Watson’s text is unchanged, but Alex Gann and Jan Witkowski have added over three hundred annotations on the events and characters portrayed, with facsimile letters and contemporary photographs, many previously unpublished. Their sources include newly discovered correspondence from Crick, the papers of Franklin, Pauling, and Wilkins, and they include a chapter dropped from the original edition.
The Double Helix is recognized by the Library of Congress as “A Book That Shaped America”. This new edition, published to mark the 50th anniversary of the Nobel Prize for Watson, Crick, and Wilkins, and the 60th anniversary of the discovery itself, adds depth and richness to one of the most famous stories in science.
“The Double Helix is the best book I know about a scientific discovery—this new edition suffuses the whole with social history, fascinating documentation, photography, and cunning background research. The early fifties, the beginning of the modern age of molecular biology, spring to life.“ ——Ian McEwan, author of Atonement
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